185038-85-1

Basic information

• Product Name: Benzoic acid, 2-hydroxy-6-methoxy-4-(phenylmethoxy)-, methyl ester
• CAS NO: 185038-85-1
• Molecular Formula: C16H16O5
• Molecular Weight: 288.3
• Mol File: 185038-85-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-hydroxy-6-methoxy-4-(phenylmethoxy)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-hydroxy-6-methoxy-4-(phenylmethoxy)-, methyl ester(185038-85-1)
• EPA Substance Registry System: Benzoic acid, 2-hydroxy-6-methoxy-4-(phenylmethoxy)-, methyl ester(185038-85-1)

Safety Data

• Hazardous Substances Data: 185038-85-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 77376-71-7 methyl 4-(benzyloxy)-2,6-dihydroxybenzoate 
• 186581-53-3 diazomethane 

Downstream Products

• 185038-90-8 (R)-3,4,5,6,7,8,9,10-Octahydro-12-benzyloxy-14-methoxy-3-methyl-5,5-(prop-1,3-ylenedithio)-1H-2-benzoxacyclododecin-1-one 
• 185038-91-9 (S)-3,4,5,6,7,8,9,10-Octahydro-12-benzyloxy-14-methoxy-3-methyl-5,5-(prop-1,3-ylenedithio)-1H-2-benzoxacyclododecin-1-one 
• 185038-88-4 4-Benzyloxy-2-{5-[2-((S)-2-hydroxy-propyl)-[1,3]dithian-2-yl]-pentyl}-6-methoxy-benzoic acid methyl ester 
• 185038-89-5 (S)-4-Benzyloxy-2-methoxy-6-{5-[2-(2-hydroxypropyl)-1,3-dithian-2-yl]pentyl}benzoic acid 
• 32885-81-7 (3S)-lasiodiplodin 
• 185038-86-2 4-Benzyloxy-2-methoxy-6-trifluoromethanesulfonyloxy-benzoic acid methyl ester 

Relevant articles and documents

Total synthesis of virgatolide b via exploitation of intramolecular hydrogen bonding

A full account of the enantioselective total synthesis of virgatolide B is reported. Key features of the synthesis include an sp3-sp2 Suzuki-Miyaura cross-coupling of a β-trifluoroboratoamide with an aryl bromide, regioselective intramolecular carboalkoxylation, and a 1,3-anti-selective Mukaiyama aldol reaction. Intramolecular hydrogen bonding governed the regioselectivity of the key spiroketalization step, affording the natural product as a single regioisomer.