185040-27-1

Usage

Uses

Used in Pharmaceutical Industry:
4-(methylamino)-2-(methylsulfanyl)pyrimidine-5-carbonitrile is used as an intermediate in the synthesis of pharmaceuticals for its potential biological activity. Its structure suggests that it may have applications in the development of antiviral and anticancer agents, among other medicinal uses.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(methylamino)-2-(methylsulfanyl)pyrimidine-5-carbonitrile is employed as a building block in the creation of agrochemicals, leveraging its potential to exhibit biological activity beneficial for crop protection and enhancement.
Further research is necessary to fully explore the properties and potential applications of 4-(methylamino)-2-(methylsulfanyl)pyrimidine-5-carbonitrile, as its current uses are based on its chemical structure and the preliminary findings of its biological activity.

Upstream product

• 74-89-5 methylamine 
• 33089-15-5 4-chloro-5-cyano-2-methylthiopyrimidine 

Downstream Products

• 214983-14-9 4-methylamino-2-phenylamino-pyrimidine-5-carbonitrile 
• 185040-32-8 4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde 
• 1229980-02-2 4-(methylamino)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidine-5-carbonitrile 
• 214983-17-2 (6-Biphenyl-4-yl-7-imino-8-methyl-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)-phenyl-amine 
• 214983-16-1 (7-Imino-8-methyl-6-thiophen-2-yl-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)-phenyl-amine 
• 214983-15-0 4-methylamino-2-phenylamino-pyrimidine-5-carbaldehyde 

Relevant academic research and scientific papers

DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE

The present invention relates to a compound of General Formula (I) below, among others. In the Formula, Ar1 is an optionally substituted aryl or heteroaryl group; R1 is a hydrogen atom, an optionally substituted C1-C6 alkyl group, or an optionally substituted aryl, aralkyl, or heteroaryl group; R2 is an optionally substituted aryl, aralkyl, or heteroaryl group; and R3 is a hydrogen atom or a C1-C6 alkyl group. A compound of the present invention has an excellent Wee1 kinase inhibiting effect, and is therefore useful in the filed of medicine, particularly in various types of cancer therapy.

Synthesis and tyrosine kinase inhibitory activity of a series of 2- amino-8H-pyrido[2,3-d]pyrimidines: Identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors

Screening of a compound library led to the identification of 2-amino-6- (2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidine (1) as a inhibitor of the platelet-derived growth factor receptor (PDGFr), fibroblast growth factor receptor (FGFr), and c-src tyrosine kinases (TKs). Replacement of the primary amino group at C-2 of 1 with a 4-(N,N-diethylaminoethoxy)phenylamino group yielded 2a, which had greatly increased activity against all three TKs. In the present work, variation of the aromatic group at C-6 and of the alkyl group at N-8 of the pyrido[2,3d]pyrimidine core provided several analogues that retained potency, including derivatives that were biased toward inhibition of the TK activity of PDGFr. Analogues of 2a with a 3-thiophene or an unsubstituted phenyl group at C-6 were the most potent inhibitors. Compound 54, which had IC50 values of 31, 88, and 31 nM against PDGFr, FGFr, and c-src TK activity, respectively, was active in a variety of PDGF- dependent cellular assays and blocked the in vivo growth of three PDGF- dependent tumor lines.