18505-18-5

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 1013-45-2 2,4,6-Trichlorphenoxy(trimethyl)silan 

Downstream Products

• 15013-29-3 2,4,6-Tris-(trimethylsilyl)-phenol 
• 17864-01-6 2,4-bis(trimethylsilyl)phenyl trimethylsilyl ether 
• 18036-70-9 2,4-Bis-(trimethylsilyl)-phenol 

Relevant academic research and scientific papers

2-(Trimethylsilyl)phenyl Trimethylsilyl Ethers as Stable and Readily Accessible Benzyne Precursors

Stable 2-(trimethylsilyl)phenyl trimethylsilyl ethers, readily obtained from the corresponding halogenated phenols in two steps, were identified as novel benzyne precursors. These species were converted to benzynes by a domino reaction of O-desilylation,

Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation

The present invention relates to novel specifically-substituted phenyl compounds, especially substituted di-tert-butyl phenol derivatives, which are effective as anti-inflammatory, analgesic and/or antipyretic agents. These phenyl compounds are substituted with a low molecular weight alkyl chain which terminates in a specific unsaturated functional group. These unsaturated functionalities are --C CH, C=CH2, C=C=CH2, and aldehydes in the form of their acetals. The present invention further relates to pharmaceutical compositions which contain an anti-inflammatory agent of the present invention and a pharmaceutically-acceptable carrier. Finally, the present invention relates to methods for treating diseases characterized by inflammation, such as rheumatoid arthritis and osteoarthritis, in humans or lower animals. Such methods comprise administering to a human or lower animal in need of such treatment a safe and effective amount of an anti-inflammatory agent or composition of the present invention.