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185057-50-5 Usage

General Description

N-Cbz-3-aminopyrrolidine is a chemical compound that consists of a pyrrolidine ring with an attached amino group and a carbobenzyloxy (Cbz) protecting group. It is commonly used in organic synthesis as a building block for the preparation of various compounds. The Cbz protecting group serves to block the reactivity of the amino group during chemical reactions until it is selectively removed, allowing for the formation of specific products. N-Cbz-3-aminopyrrolidine has applications in medicinal chemistry, particularly in the synthesis of potential drug candidates, as well as in the development of various other organic molecules. The compound is known for its versatility and utility in a wide range of chemical transformations, making it a valuable tool for synthetic chemists.

Check Digit Verification of cas no

The CAS Registry Mumber 185057-50-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,0,5 and 7 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 185057-50:
145 % 10 = 5
So 185057-50-5 is a valid CAS Registry Number.

185057-50-5 Well-known Company Product Price

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  • Alfa Aesar

  • (H28525)  (±)-3-Amino-1-(benzyloxycarbonyl)pyrrolidine   

  • 185057-50-5

  • 250mg

  • 615.0CNY

  • Detail
  • Alfa Aesar

  • (H28525)  (±)-3-Amino-1-(benzyloxycarbonyl)pyrrolidine   

  • 185057-50-5

  • 1g

  • 1588.0CNY

  • Detail
  • Alfa Aesar

  • (H28525)  (±)-3-Amino-1-(benzyloxycarbonyl)pyrrolidine   

  • 185057-50-5

  • 5g

  • 4880.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017


1.1 GHS Product identifier

Product name Benzyl 3-Aminopyrrolidine-1-carboxylate

1.2 Other means of identification

Product number -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:185057-50-5 SDS

185057-50-5Relevant articles and documents

Design, synthesis and SAR of antitubercular benzylpiperazine ureas

Satish, Sohal,Chitral, Rohan,Kori, Amitkumar,Sharma, Basantkumar,Puttur, Jayashree,Khan, Afreen A.,Desle, Deepali,Raikuvar, Kavita,Korkegian, Aaron,Martis, Elvis A. F.,Iyer, Krishna R.,Coutinho, Evans C.,Parish, Tanya,Nandan, Santosh

, p. 73 - 96 (2021/01/04)

Abstract: N-furfuryl piperazine ureas disclosed by scientists at GSK Tres Cantos were chosen as antimycobacterial hits from a phenotypic whole-cell screen. Bioisosteric replacement of the furan ring in the GSK Tres Cantos molecules with a phenyl ring led to molecule (I) with an MIC of 1?μM against Mtb H37Rv, low cellular toxicity (HepG2 IC50 ~ 80?μM), good DMPK properties and specificity for Mtb. With the aim of delineating the SAR associated with (I), fifty-five analogs were synthesized and screened against Mtb. The SAR suggests that the piperazine ring, benzyl urea and piperonyl moieties are essential signatures of this series. Active compounds in this series are metabolically stable, have low cellular toxicity and are valuable leads for optimization. Molecular docking suggests these molecules occupy the Q0 site of QcrB like Q203. Graphic Abstract: Bioisosteric replacement of N-furfuryl piperazine-1-carboxamides yielded molecule (I) a novel lead with satisfactory PD, metabolism, and toxicity profiles.[Figure not available: see fulltext.]



Page/Page column 112, (2009/12/05)

The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R1a is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R1b is an optionally substituted C1-6 alkoxy, etc.; R1c is a hydrogen atom, an optionally substituted C1-6 alkoxy, etc.; R2 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, -(CH2)sO-, - (CH2)sN(R4)CO-, etc., B is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.), etc.; R4 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.

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