185063-82-5

Basic information

• Product Name: (4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester
• Synonyms: (4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester
• CAS NO: 185063-82-5
• Molecular Formula: C₁₅H₂₃NO₃
• Molecular Weight: 265.34802
• Mol File: 185063-82-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester(185063-82-5)
• EPA Substance Registry System: (4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester(185063-82-5)

Safety Data

• Hazardous Substances Data: 185063-82-5(Hazardous Substances Data)

Usage

Description

(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester, also known as tiocarbazil, is a synthetic chemical compound with potent fungicidal properties. It is characterized by its ability to inhibit fungal growth by disrupting cell structure and interfering with fungal metabolism, making it a valuable asset in agricultural practices.
Used in Agricultural Industry:
(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester is used as a fungicide for controlling a broad spectrum of plant diseases. It is effective against common afflictions such as powdery mildew, leaf spot, and rust, thereby protecting crops and ensuring a healthy yield.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1128-28-5 4-aminothymol 

Downstream Products

• 185064-22-6 2-(1-Benzyl-2-ethyl-6-isopropyl-5-methoxy-1H-indol-3-yl)-acetamide 
• 185064-19-1 1-Benzyl-2-ethyl-6-isopropyl-5-methoxy-1H-indole 
• 1027658-55-4 2-(1-Benzyl-2-ethyl-6-isopropyl-5-methoxy-1H-indol-3-yl)-2-hydroxy-acetamide 
• 1027852-36-3 (1-Benzyl-2-ethyl-6-isopropyl-5-methoxy-1H-indol-3-yl)-oxo-acetyl chloride 
• 185064-25-9 2-(1-Benzyl-2-ethyl-6-isopropyl-5-methoxy-1H-indol-3-yl)-2-oxo-acetamide 
• 185063-86-9 [5-Isopropyl-4-methoxy-2-(2-oxo-butyl)-phenyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides

Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been detected in several pathological conditions. An inhibitor of this enzyme could have therapeutic utility. A broad screening program was carried out to identify chemical structures which could inhibit hnps-PLA2. One of the lead compounds generated by the screening program was 5-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid (13a). We describe the syntheses, structure-activity relationships, and pharmacological activities of a series of indole-3-acetamides and related compounds derived from this lead. This SAR was undertaken with the aid of X- ray crystal structures of complexes between the inhibitors and hnps-PLA2 which were of great value in directing the SAR.