185066-40-4

Usage

Chemical structure

A complex structure consisting of a 1-butanone ketone compound and a piperidine derivative with substituted phenyl groups.

Functional groups

Contains hydroxydiphenylmethyl and 1-methylethyl groups, which add complexity to the molecule.

Molecular weight

Approximately 437.58 g/mol (calculated from the molecular formula)

Potential applications

Due to its intricate structure and potential chemical reactivity, 1-Butanone, 4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-[4-(1-methylethyl)phenyl]- may have diverse applications in pharmaceuticals, organic synthesis, and as a research reagent.

Further analysis

Additional research and analysis are necessary to fully understand the properties and functions of 1-Butanone, 4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-[4-(1-methylethyl)phenyl]-.

Solubility

The solubility of 1-Butanone, 4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-[4-(1-methylethyl)phenyl]- is not provided in the material, but it may be influenced by the presence of polar and nonpolar functional groups.

Stability

The stability of 1-Butanone, 4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-[4-(1-methylethyl)phenyl]- is not mentioned in the material, but it may be affected by factors such as temperature, light, and exposure to air or moisture.

Reactivity

The reactivity of 1-Butanone, 4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-[4-(1-methylethyl)phenyl]- is not specified in the material, but its complex structure suggests that it may have potential reactivity with other chemical compounds.

Safety and handling

Information on safety and handling precautions is not provided in the material, but due to its complex structure, it is essential to follow standard laboratory safety protocols when handling 1-Butanone, 4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-[4-(1-methylethyl)phenyl]-.

Upstream product

• 115-46-8 C₁₈H₂₁NO 
• 70289-38-2 4-Chloro-1-(4-isopropyl-phenyl)-butan-1-one 
• 98-82-8 Isopropylbenzene 

Downstream Products

• 1313731-46-2 tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-isopropylphenyl)butan-1-oxy)dimethylsilane 
• 1313731-47-3 tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-(2-bromopropan-2-yl)phenyl)butan-1-oxy)dimethylsilane 
• 83799-24-0 fexofenadine 

Relevant academic research and scientific papers

METHODS AND COMPOSITIONS FOR TREATING INFECTION

Provided herein are compositions and methods for treating or preventing infection.

Repurposing the antihistamine terfenadine for antimicrobial activity against staphylococcus aureus

Staphylococcus aureus is a rapidly growing health threat in the U.S., with resistance to several commonly prescribed treatments. A high-throughput screen identified the antihistamine terfenadine to possess, previously unreported, antimicrobial activity against S. aureus and other Gram-positive bacteria. In an effort to repurpose this drug, structure-activity relationship studies yielded 84 terfenadine-based analogues with several modifications providing increased activity versus S. aureus and other bacterial pathogens, including Mycobacterium tuberculosis. Mechanism of action studies revealed these compounds to exert their antibacterial effects, at least in part, through inhibition of the bacterial type II topoisomerases. This scaffold suffers from hERG liabilities which were not remedied through this round of optimization; however, given the overall improvement in activity of the set, terfenadine-based analogues provide a novel structural class of antimicrobial compounds with potential for further characterization as part of the continuing process to meet the current need for new antibiotics.

Novel and efficient method for the synthesis of racemic fexofenadine

Fexofenadine is a selective H1-histamine receptor antagonist, which is an attractive alternative treatment for allergy symptoms. An efficient and environmentally friendly synthetic approach for the preparation of fexofenadine was developed from commercially available cumene. The method involves the Friedel-Craft's reaction, substitution, reduction, bromination, and the Grignard reaction. Copyright

Identification of terfenadine as an inhibitor of human CD81-receptor HCV-E2 interaction: Synthesis and structure optimization

Terfenadine (4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-(4-tert- butylphenyl)-butan-1-ol) was identified in a biological screening to be a moderate inhibitor (27 % inhibition) of the CD81-LEL-HCV-E2 interaction. To increase the observed biological activity, 63 terfenadine derivates were synthesized via microwave assisted nucleophilic substitution. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay using HUH7.5 cells. Distinct structure-activity relationships could be derived. Optimization was successful, leading to 3g, identfied as the most potent compound (69 % inhibition). Experiments with viral particles revealed that there might be additional HCV infection reducing mechanisms.