185068-45-5Relevant academic research and scientific papers
Acyloxymethyl and 4-acyloxybenzyl diester prodrugs of phosphonoformate
Briggs, Andrew D.,Camplo, Michel,Freeman, Sally,Lundstroem, Jan,Pring, Brian G.
, p. 14937 - 14950 (1996)
Sodium pivaloyloxymethyl (pivaloyloxymethoxycarbonyl)phosphonate 4, sodium 4-acyloxybenzyl phenoxycarbonylphosphonates 14a-c and sodium 4-acyloxybenzyl benzyloxycarbonylphosphonates 15a,b have been prepared as bioreversible prodrugs of the antiviral phosphonoformate 1. Their hydrolyses, in vivo systemic bioavailability and antiviral activity are reported. Of the compounds evaluated 4 was the best prodrug.
