Tetrahedron p. 14937 - 14950 (1996)
Update date:2022-08-02
Topics:
Briggs, Andrew D.
Camplo, Michel
Freeman, Sally
Lundstroem, Jan
Pring, Brian G.
Sodium pivaloyloxymethyl (pivaloyloxymethoxycarbonyl)phosphonate 4, sodium 4-acyloxybenzyl phenoxycarbonylphosphonates 14a-c and sodium 4-acyloxybenzyl benzyloxycarbonylphosphonates 15a,b have been prepared as bioreversible prodrugs of the antiviral phosphonoformate 1. Their hydrolyses, in vivo systemic bioavailability and antiviral activity are reported. Of the compounds evaluated 4 was the best prodrug.
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(1996)
