Tetrahedron p. 14937 - 14950 (1996)
Update date:2022-08-02
Topics:
Briggs, Andrew D.
Camplo, Michel
Freeman, Sally
Lundstroem, Jan
Pring, Brian G.
Sodium pivaloyloxymethyl (pivaloyloxymethoxycarbonyl)phosphonate 4, sodium 4-acyloxybenzyl phenoxycarbonylphosphonates 14a-c and sodium 4-acyloxybenzyl benzyloxycarbonylphosphonates 15a,b have been prepared as bioreversible prodrugs of the antiviral phosphonoformate 1. Their hydrolyses, in vivo systemic bioavailability and antiviral activity are reported. Of the compounds evaluated 4 was the best prodrug.
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Doi:10.1246/cl.2003.712
(2003)Doi:10.1021/jo982528g
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(1996)Doi:10.1016/S0022-1139(00)82737-2
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(1996)
