185110-16-1 Usage
General Description
1-BOC-3-(3,4-DICHLOROPHENYL)PIPERAZINE is a chemical compound that belongs to the class of piperazine derivatives. It is characterized by the presence of a BOC (tert-butoxycarbonyl) protecting group and a 3-(3,4-dichlorophenyl) substituent on the piperazine ring. 1-BOC-3-(3,4-DICHLOROPHENYL)PIPERAZINE has potential applications in medicinal chemistry and drug discovery, particularly in the development of pharmaceutical agents targeting the central nervous system and other biological targets. Its unique structural features make it a valuable building block for the synthesis of novel compounds with potential therapeutic properties. In addition, the BOC protecting group provides stability and facilitates the manipulation of the molecule in chemical reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 185110-16-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,1,1 and 0 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 185110-16:
(8*1)+(7*8)+(6*5)+(5*1)+(4*1)+(3*0)+(2*1)+(1*6)=111
111 % 10 = 1
So 185110-16-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H20Cl2N2O2/c1-15(2,3)21-14(20)19-7-6-18-13(9-19)10-4-5-11(16)12(17)8-10/h4-5,8,13,18H,6-7,9H2,1-3H3
185110-16-1Relevant articles and documents
Synthesis and NK1/NK2 binding activities of a series of diacyl-substituted 2-arylpiperazines
Blythin, David J.,Chen, Xiao,Piwinski, John J.,Shih, Neng-Yang,Shue, Ho-Jane,Anthes, John C.,McPhail, Andrew T.
, p. 3161 - 3165 (2007/10/03)
The synthesis and binding affinity for hNK1 and hNK2 receptors of a series of diacyl substituted 2-aryl piperazines are described. SAR evaluation led to the racemic derivative 11g as an apparent dual inhibitor. Chiral chromatographic separation of 11g led to the observation that NK1 activity was shown by one enantiomer (13a) and NK2 activity was shown by the other enantiomer (13b). X-ray crystallographic analysis of the crystalline di-BOC derivative of the NK2 active piperazine (15) showed that the 2R configuration was associated with NK2 activity. Further derivatization indicated that dual NK1/NK2 activity could be built into the 2R series.
