18514-46-0

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C23H23NO2/c1-2-26-22(25)18-24-23(19-12-6-3-7-13-19,20-14-8-4-9-15-20)21-16-10-5-11-17-21/h3-17,24H,2,18H2,1H3

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 76-83-5 trityl chloride 
• 5824-40-8 Triphenylmethylamin 
• 105-39-5 chloroacetic acid ethyl ester 
• 64-17-5 ethanol 
• 78646-25-0 4-dimethylamino-1-N-(triphenylmethyl)pyridinium chloride 

Downstream Products

• 5893-05-0 Trt-Gly 
• 80239-63-0 N-(3-amino-2-hydroxypropyl)-2-(tritylamino)acetamide 
• 80224-33-5 N-<2-hydroxy-3-<2-(tritylamino)acetamido>propyl>methacrylamide 
• 174836-16-9 N-triphenylmethyl-2,2-dideuterioethanolamine 
• 75934-52-0 ethyl N-nitroso-N-(triphenylmethyl)glycinate 

Relevant academic research and scientific papers

Preparation method for N-triphenyl methyl-glycine ethyl ester

The invention discloses a preparation method for N-triphenyl methyl-glycine ethyl ester, and mainly aims at solving the technical problems that in an original synthesis technology, the reaction time is long, the yield is low, and the cost is high. Accordi

Stereospecific synthesis of tetradeuterated (R)- and (S)-ifosfamide

The tetradeuterated analogues of (R)- and (S)-ifosfamide [(S)- and (R)-2-(2-chloro-2,2-dideuterioethyl)amino-3-(2-chloroethyl)-6,6-dideuterio -tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide, (S)- and (R)-1-d4] were synthesized by modification of a

SYNTHESIS AND CHARACTERIZATION OF 4-DIMETHYLAMINO-N-TRIPHENYLMETHYLPYRIDINIUM CHLORIDE, A POSTULATED INTERMEDIATE IN THE TRITYLATION OF ALCOHOLS

4-Dimethylamino-N-triphenylpyridinium chloride (1) reacts with primary but not secondary alcohols to produce trityl ethers in good yield; in addition, amines may be selectively N-tritylated with 1 in the presence of alcohols.

Imidazole derivatives with potential biological activity

A series of 1-substituted imidazole-5-carbohydroxamic acids Ia, Ib and Ie were prepared from the corresponding 5-methoxycarbonyl imidazoles (IX) obtained by a univocal synthesis starting with the reaction of the amines (III) with ethylchloroacetate. On treatment of 4(5)-methoxycarbonyl imidazoles (XI) with alkylar halides (X), on the contrary, mixtures of 1-substituted-4(or 5)-methoxycarbonyl imidazoles were obtained that, when separated by thin-layer chromatography, gave the carbohydroxamic acids Ia, Ib, Id and Ie and IIa→f. The structures of the imidazole derivatives were obtained by means of IR, NMR and UV spectra. On carrying out tests of biological activity on these compounds, it had been found that the 5-carbohydroxamic acids possess, compared to the 4-carbohydroxamic ones, a greater activity. Particularly Ib and Ib-HCl seem fairly active against Klebsiella pneumoniae and Clostridium bifermentans, Ib-HCl against Bacillus subtilis, too.