185207-73-2Relevant academic research and scientific papers
Identification of 4-quinolone derivatives as inhibitors of reactive oxygen species production from human umbilical vein endothelial cells
Onda, Kenichi,Narazaki, Fumie,Ishibashi, Naoki,Nakanishi, Keita,Sawada, Yuki,Imamura, Ken-Ichiro,Momose, Kazuhiro,Furukawa, Shigetada,Shimada, Yoshiaki,Moriguchi, Hiroyuki,Yuda, Masamichi,Kayakiri, Hiroshi,Ohta, Mitsuaki
, p. 6861 - 6866 (2012/01/03)
Oxidative stress is widely recognized as being associated with a number of disorders, including metabolic dysfunction and atherosclerosis. A series of substituted 4-quinolone derivatives were prepared and evaluated as inhibitors of reactive oxygen species (ROS) production from human umbilical vein endothelial cells (HUVECs). One compound in particular, 2-({[4-(3-hydroxy-3-methylbutoxy) pyridin-2-yl]oxy}methyl)-3-methylquinolin-4(1H)-one (25b), inhibited ROS production from HUVECs with an IC50 of 140 nM. This compound also exhibited low CYP2D6 inhibitory activity, high aqueous solubility, and good in vitro metabolic stability. An in vivo pharmacokinetic study of this compound in SD rats revealed high oral bioavailability and a long plasma half-life.
