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Usage

Uses

Used in Dye and Pigment Manufacturing:
2-chloro-1,3,8-trihydroxy-6-methylanthracene-9,10-dione is used as a colorant in the production of dyes and pigments for its intense red color. Its unique properties make it suitable for creating a wide range of hues and shades in various applications.
Used in Textile Industry:
In the textile industry, 2-chloro-1,3,8-trihydroxy-6-methylanthracene-9,10-dione is used as a dyeing agent for imparting vibrant red colors to fabrics. Its colorfastness and stability make it a preferred choice for various textile products.
Used in Paper Industry:
2-chloro-1,3,8-trihydroxy-6-methylanthracene-9,10-dione is utilized as a pigment in the paper industry to achieve specific color effects in paper products. Its intense red color can be used for decorative or functional purposes in various types of paper.
Used in Pharmaceutical Industry:
Due to its structural properties, 2-chloro-1,3,8-trihydroxy-6-methylanthracene-9,10-dione has potential applications in the pharmaceutical industry. It can be used as an active pharmaceutical ingredient or as a component in drug formulations, depending on its bioactivity and pharmacological properties.
Used in Agrochemical Industry:
2-chloro-1,3,8-trihydroxy-6-methylanthracene-9,10-dione may also find use in the agrochemical industry, where it could be employed as a component in the development of pesticides, herbicides, or other agricultural chemicals, based on its chemical properties and potential interactions with biological systems.
As a synthetic chemical, it is crucial to handle and use 2-chloro-1,3,8-trihydroxy-6-methylanthracene-9,10-dione with caution, adhering to proper safety guidelines and regulations to ensure the safety of both the environment and individuals involved in its production and application.

Upstream product

• 518-82-1 1,6,8-trihydroxy-3-methyl-9,10-anthraquinone 

Relevant academic research and scientific papers

Chlorination of anthraquinones by lichen and fungal enzymes

Chlorination of the anthraquinones, emodin and 7-chloroemodin, was studied with an enzyme preparation from the lichen Nephroma laevigatum, and a commerically available fungal chloroperoxidase (EC 1.11.1.10). The fungal enzyme converted emodin to a mixture of 5-chloro, 7-chloro and 5,7- dichloroemodin, while converting the 7-chloro isomer to 5,7-dichloroemodin in nearly quantitative yield. The lichen enzyme, however, chlorinated emodin only at C-7 and failed to chlorinate 7-chloroemodin further. In non-enzymic controls, emodin gave the same set of products as the fungal enzyme but 7- chloroemodin did not undergo further chlorination. The chemical structures of the products were confirmed from UV, El-mass and 1H NMR spectral data.

Antiviral activities of halogenated emodin derivatives against human coronavirus nl63

The current COVID-19 outbreak has highlighted the need for the development of new vaccines and drugs to combat Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Recently, various drugs have been proposed as potentially effective against COVID-19, such as remdesivir, infliximab and imatinib. Natural plants have been used as an alternative source of drugs for thousands of years, and some of them are effective for the treatment of various viral diseases. Emodin (1,3,8-trihydroxy-6-methylanthracene-9,10-dione) is a biologically active anthraquinone with antiviral activity that is found in various plants. We studied the selectivity of electrophilic aromatic substitution reactions on an emodin core (halogenation, nitration and sulfonation), which resulted in a library of emodin derivatives. The main aim of this work was to carry out an initial evaluation of the potential to improve the activity of emodin against human coronavirus NL63 (HCoV-NL63) and also to generate a set of initial SAR guidelines. We have prepared emodin derivatives which displayed significant anti-HCoV-NL63 activity. We observed that halogenation of emodin can improve its antiviral activity. The most active compound in this study was the iodinated emodin analogue E_3I, whose anti-HCoV-NL63 activity was comparable to that of remdesivir. Evaluation of the emodin analogues also revealed some unwanted toxicity to Vero cells. Since new synthetic routes are now available that allow modification of the emodin structure, it is reasonable to expect that analogues with significantly improved anti-HCoV-NL63 activity and lowered toxicity may thus be generated.

Compound for preventing and treating viral diseases and application thereof

The invention discloses a compound for preventing and treating viral diseases and application thereof, relates to the technical field of medicines, and the activity of viruses can be obviously inhibited. The compound for preventing and treating virus diseases is an anthraquinone compound, a pharmaceutically acceptable salt of the anthraquinone compound and/or a pharmaceutically acceptable carrierof the anthraquinone compound. Experiments prove that the compound for preventing and treating the viral diseases has universality of an antiviral effect, for example, the activity of coronavirus HcoV-OC43, COVID-19, influenza A virus H1N1, influenza B virus and HIV virus can be remarkably inhibited; the effect of the compound is obviously superior to that of a parent nucleus compound emodin and an emodin derivative. Compared with clinical first-line drugs, the ribavirin, zidovudine and acyclovir pharmaceutical composition has more remarkable activity and better effects than ribavirin, zidovudine and acyclovir; the compound for preventing and treating virus diseases also has the characteristics of simple preparation method, economical raw materials, low cost and convenience in industrial production.

Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase

Aberrant cellular metabolism drives cancer proliferation and metastasis. ATP citrate lyase (ACL) plays a critical role in generating cytosolic acetyl CoA, a key building block for de novo fatty acid and cholesterol biosynthesis. ACL is overexpressed in ca