185223-40-9

Basic information

• Product Name: 6H-1,2-Oxazine-3-carboxylicacid,ethylester(9CI)
• Synonyms: 6H-1,2-Oxazine-3-carboxylicacid,ethylester(9CI)
• CAS NO: 185223-40-9
• Molecular Formula: C7H9NO3
• Molecular Weight: 0
• Product Categories: CARBOXYLICESTER;GLYCINESCAFFOLD
• Mol File: 185223-40-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6H-1,2-Oxazine-3-carboxylicacid,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-1,2-Oxazine-3-carboxylicacid,ethylester(9CI)(185223-40-9)
• EPA Substance Registry System: 6H-1,2-Oxazine-3-carboxylicacid,ethylester(9CI)(185223-40-9)

Safety Data

• Hazardous Substances Data: 185223-40-9(Hazardous Substances Data)

Upstream product

• 185223-34-1 (E)-5-Bromo-2-oxo-pent-3-enoic acid ethyl ester 
• 118653-61-5 (E)-ethyl 2-oxo-3-pentenoate 

Relevant articles and documents

Indole-3-pyruvic acid oxime ethers and thieno analogues by heck cyclisation. Application to the synthesis of thia-tryptophans

N-allylation of N-BOC substituted o-iodo anilines (14a-e) and thienoamines (16,18,20) employing methyl or benzyl oxime ethers of ethyl (E)-2-oxo-5-bromo-3-pentenoate 2a, followed by palladium-catalysed Heck cyclisation yielded oxime ethers of Bz-substituted ethyl indole-3-pyruvates (15a-f) and thienopyrroles (17,19,21-23). Attempted conversion of 2a into the corresponding tosyl hydrazone or oxime resulted in formation of pyridazine (10) and oxazine (13) derivatives. The three possible isomers of thia-tryptophan were obtained as the ethyl esters from corresponding methyl oxime ethers by reduction of the oxime double bond.