185254-72-2Relevant academic research and scientific papers
Conversion of the phytoestrogen coumestrol into a selective estrogen receptor modulator (SERM) by attachment of an amine-containing sidechain
Grese, Timothy A.,Cole, Harlan W.,Magee, David E.,Phillips, D. Lynn,Shetler, Pam K.,Short, Lorri L.,Glasebrook, Andrew L.,Bryant, Henry U.
, p. 2683 - 2686 (1996)
The naturally occurring estrogen mimetic coumestrol has been shown to stimulate proliferation of MCF-7 mammary tumor cells and to cause uterotrophic effects in ovariectomized (OVX) rats. Attachment of a basic amine-containing sidechain to C-6 of coumestrol converts this estrogen agonist into an antagonist in breast and uterine tissue, while maintaining its estrogen-like activity as a hypocholesterolemic agent.
