Bioorganic and Medicinal Chemistry Letters p. 2683 - 2686 (1996)
Update date:2022-08-03
Topics:
Grese, Timothy A.
Cole, Harlan W.
Magee, David E.
Phillips, D. Lynn
Shetler, Pam K.
Short, Lorri L.
Glasebrook, Andrew L.
Bryant, Henry U.
The naturally occurring estrogen mimetic coumestrol has been shown to stimulate proliferation of MCF-7 mammary tumor cells and to cause uterotrophic effects in ovariectomized (OVX) rats. Attachment of a basic amine-containing sidechain to C-6 of coumestrol converts this estrogen agonist into an antagonist in breast and uterine tissue, while maintaining its estrogen-like activity as a hypocholesterolemic agent.
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(1996)Doi:10.1016/S0960-894X(96)00533-1
(1996)Doi:10.1055/s-1997-1273
(1997)Doi:10.1039/dt9960004155
(1996)Doi:10.1002/hlca.19960790817
(1996)Doi:10.1021/ja9628462
(1996)
