185298-25-3 Usage
Structure
Five-membered ring with a nitrogen atom
The compound is characterized by a central ring containing a nitrogen atom
Methyl group attachment
Indole ring
A methyl group is attached to the indole ring, contributing to its structure
2-methylphenylmethyl group
Side chain
A 2-methylphenylmethyl group is connected to the main indole ring, further defining the compound's structure
Potential applications
Pharmaceuticals, organic synthesis, building blocks
The compound may have various uses in the pharmaceutical industry, organic synthesis, and as a component in creating more complex molecules
Structural features
Interesting for further studies and potential uses
The unique structure of the compound makes it an intriguing molecule for research and possible applications across different industries
Check Digit Verification of cas no
The CAS Registry Mumber 185298-25-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,2,9 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 185298-25:
(8*1)+(7*8)+(6*5)+(5*2)+(4*9)+(3*8)+(2*2)+(1*5)=173
173 % 10 = 3
So 185298-25-3 is a valid CAS Registry Number.
185298-25-3Relevant academic research and scientific papers
Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides
Draheim, Susan E.,Bach, Nicholas J.,Dillard, Robert D.,Berry, Dennis R.,Carlson, Donald G.,Chirgadze, Nickolay Y.,Clawson, David K.,Hartley, Lawrence W.,Johnson, Lea M.,Jones, Noel D.,McKinney, Emma R.,Mihelich, Edward D.,Olkowski, Jennifer L.,Schevitz, Richard W.,Smith, Amy C.,Snyder, David W.,Sommers, Cynthia D.,Wery, Jean-Pierre
, p. 5159 - 5175 (2007/10/03)
The preceding papers of this series detail the development of functionalized indole-3-acetamides as inhibitors of hnps-PLA2. We describe here the extension of the structure-activity relationship to include a series of indole-3-glyoxamide derivatives. Functionalized indole-3-glyoxamides with an acidic substituent appended to the 4- or 5-position of the indole ring were prepared and tested as inhibitors of hnps-PLA2. It was found that the indole-3-glyoxamides with a 4-oxyacetic acid substituent had optimal inhibitory activity. These inhibitors exhibited an improvement in potency over the best of the indole-3-acetamides, and LY315920 (6m) was selected for evaluation clinically as an hnps-PLA2 inhibitor.
