185299-13-2 Usage
Uses
Used in Pharmaceutical Industry:
1H-Indol-4-ol, 1-[(2-chlorophenyl)methyl]-2-methylis utilized as a key building block for the synthesis of a variety of bioactive molecules, including antiviral, antibacterial, and anticancer agents. Its diverse biological activities make it an essential component in drug discovery and development processes.
Used in Agrochemicals:
In the agrochemical industry, 1H-Indol-4-ol, 1-[(2-chlorophenyl)methyl]-2-methylhas potential applications, contributing to its significance in this field. Its specific use cases in agrochemicals are not detailed in the provided materials.
Used in Material Science:
1H-Indol-4-ol, 1-[(2-chlorophenyl)methyl]-2-methylalso holds promise in material science, where it may be employed to develop new materials or enhance existing ones. The exact applications in material science are not specified in the provided materials but indicate its broad utility across different scientific disciplines.
Check Digit Verification of cas no
The CAS Registry Mumber 185299-13-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,2,9 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 185299-13:
(8*1)+(7*8)+(6*5)+(5*2)+(4*9)+(3*9)+(2*1)+(1*3)=172
172 % 10 = 2
So 185299-13-2 is a valid CAS Registry Number.
185299-13-2Relevant academic research and scientific papers
Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides
Draheim, Susan E.,Bach, Nicholas J.,Dillard, Robert D.,Berry, Dennis R.,Carlson, Donald G.,Chirgadze, Nickolay Y.,Clawson, David K.,Hartley, Lawrence W.,Johnson, Lea M.,Jones, Noel D.,McKinney, Emma R.,Mihelich, Edward D.,Olkowski, Jennifer L.,Schevitz, Richard W.,Smith, Amy C.,Snyder, David W.,Sommers, Cynthia D.,Wery, Jean-Pierre
, p. 5159 - 5175 (2007/10/03)
The preceding papers of this series detail the development of functionalized indole-3-acetamides as inhibitors of hnps-PLA2. We describe here the extension of the structure-activity relationship to include a series of indole-3-glyoxamide derivatives. Functionalized indole-3-glyoxamides with an acidic substituent appended to the 4- or 5-position of the indole ring were prepared and tested as inhibitors of hnps-PLA2. It was found that the indole-3-glyoxamides with a 4-oxyacetic acid substituent had optimal inhibitory activity. These inhibitors exhibited an improvement in potency over the best of the indole-3-acetamides, and LY315920 (6m) was selected for evaluation clinically as an hnps-PLA2 inhibitor.
