185299-14-3 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule of the compound.
Explanation
Indole is the core structure of the compound, consisting of two fused rings (one six-membered and one five-membered) with one nitrogen atom.
Explanation
The compound has two main functional groups attached to the indol-4-ol core, which are a benzoyl group (C6H5CO-) and an ethyl group (C2H5-).
Explanation
The compound has been studied for its potential as a selective agonist for the serotonin 5-HT2A receptor, which is a target for the treatment of various mental health disorders.
Explanation
1H-Indol-4-ol, 1-benzoyl-2-ethylis used in organic synthesis as a building block for the preparation of other compounds, due to its unique structure and functional groups.
Explanation
As a selective agonist for the serotonin 5-HT2A receptor, the compound may have potential applications in the treatment of mental health disorders, such as schizophrenia, depression, and anxiety.
Explanation
The compound is a derivative of indole, with a benzoyl group attached to the first position and an ethyl group attached to the second position of the indol-4-ol core.
Bicyclic Heterocyclic Organic Compound
Indole
Functional Groups
Benzoyl and Ethyl
Pharmacological Properties
Selective Agonist for Serotonin 5-HT2A Receptor
Application in Organic Synthesis
Building Block for Other Compounds
Potential for Mental Health Treatment
Targeting Serotonin 5-HT2A Receptor
Chemical Structure
Derivative of Indole with Benzoyl and Ethyl Groups
Check Digit Verification of cas no
The CAS Registry Mumber 185299-14-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,2,9 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 185299-14:
(8*1)+(7*8)+(6*5)+(5*2)+(4*9)+(3*9)+(2*1)+(1*4)=173
173 % 10 = 3
So 185299-14-3 is a valid CAS Registry Number.
185299-14-3Relevant academic research and scientific papers
Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides
Draheim, Susan E.,Bach, Nicholas J.,Dillard, Robert D.,Berry, Dennis R.,Carlson, Donald G.,Chirgadze, Nickolay Y.,Clawson, David K.,Hartley, Lawrence W.,Johnson, Lea M.,Jones, Noel D.,McKinney, Emma R.,Mihelich, Edward D.,Olkowski, Jennifer L.,Schevitz, Richard W.,Smith, Amy C.,Snyder, David W.,Sommers, Cynthia D.,Wery, Jean-Pierre
, p. 5159 - 5175 (2007/10/03)
The preceding papers of this series detail the development of functionalized indole-3-acetamides as inhibitors of hnps-PLA2. We describe here the extension of the structure-activity relationship to include a series of indole-3-glyoxamide derivatives. Functionalized indole-3-glyoxamides with an acidic substituent appended to the 4- or 5-position of the indole ring were prepared and tested as inhibitors of hnps-PLA2. It was found that the indole-3-glyoxamides with a 4-oxyacetic acid substituent had optimal inhibitory activity. These inhibitors exhibited an improvement in potency over the best of the indole-3-acetamides, and LY315920 (6m) was selected for evaluation clinically as an hnps-PLA2 inhibitor.
