185310-85-4Relevant academic research and scientific papers
Synthesis and preliminary pharmacological evaluation of 3-[2-(1-aryl-piperazin-4-yl]-3,4-dihydro-3-methyl-6-R-1,2,4-benzotriaz ines
Novelli,Sparatore
, p. 551 - 558 (2007/10/03)
A set of 3-[2-(1-aryl-piperazin-4-yl)ethyl]-3,4-dihydro-3-methyl-1,2,4-benzotri azines, bearing different substituents on the aromatic nuclei, was prepared and found to be endowed with good antihypertensive activity. The simplest compound 1, subjected to a broad pharmacological screening, exhibited also analgesic and antiallergic activities and hints of hypocholesterolemic action. Moreover this compound inhibited (in vitro tests) the guinea pig ileum contractions induced by several agents, the rat vas deferens contractions induced by phenylephrine (α1 antagonism), the platelet aggregation induced by arachidonate and the tracheal tone.
