185316-43-2

Upstream product

• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 185316-42-1 4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-6-ethynylquinoline 
• 135631-90-2 4,4-dimethyl-6-bromo-2-oxo-1,2,3,4-tetrahydroquinoline 
• 185316-41-0 4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-6[(trimethylsilyl)ethynyl]quinoline 

Downstream Products

• 185316-16-9 4-(1-Isopropyl-4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-ylethynyl)-benzoic acid ethyl ester 
• 185316-17-0 ethyl 4-[(4,4-dimethyl-2-isopropoxy-3,4-dihydro-6-quinolinyl)ethynyl]benzoate 
• 185316-19-2 Ethyl 4-[(4,4-dimethyl-2-thio-1,2,3,4-tetrahydro-6quinolinyl)ethynyl]benzoate 

Relevant academic research and scientific papers

Synthesis and biological activity of 1,2,3,4-tetrahydroquinoline and 3,4-(1H)-dihydroquinolin-2-one analogs of retinoic acid

Retinoids are natural and synthetic analogs of the hormone retinoic acid. Retinoids are currently being investigated clinically as drugs in several areas, including dermatology and oncology. We report the synthesis and biological activity of a new series of potent, RAR-specific retinoids substituted with a 1,2,3,4-tetrahydroquinoline or a 3,4-1H)-dihydroquinolin-2-one group.

Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-thio-1,2,3,4-tetrahdroquinolinyl, 2-alkylthio-3,4-dihydroquinolinyl or 2-alkoxy-3,4-dihydroquinolinyl group having retinoid-like biological activity

Compounds of the formula STR1 where the symbols are defined as in the specification.