185316-60-3Relevant academic research and scientific papers
Selenium-based solid-phase synthesis of benzopyrans II: Applications to combinatorial synthesis of medicinally relevant small organic molecules
Nicolaou,Cao, Guo-Qiang,Pfefferkorn, Jeffrey A.
, p. 739 - 743 (2007/10/03)
The transfer-hydrogenation of ketones with iPrOH in the presence of a base is catalyzed by pincer-aryl ruthenium(II) complexes (see scheme, R3 = NMe2 or PPh2, X = Cl or OSO2CF3). Conversions of 90-98% are achieved without removal of the acetone by-product. The structural unit [Ru(pincer- aryl)PPh3] is stable under the reaction conditions and is preserved during the catalytic cycle. An anionic Ru(II) hydrido complex was identified as the resting state of the catalyst at the onset of the reaction.
Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines
Ding, Charles Z.,Rovnyak, George C.,Misra, Raj N.,Grover, Gary J.,Miller, Arthur V.,Ahmed, Syed Z.,Kelly, Yolanda,Normandin, Diane E.,Sleph, Paul G.,Atwal, Karnail S.
, p. 3711 - 3717 (2007/10/03)
The effect on potency and selectivity of modification at the C6 position of the cardioprotective K(ATP) opener BMS-180448 (2) is described. Structure- activity studies show that a variety of electron-withdrawing groups (ketone, sulfone, sulfonamide, etc.)
A Convenient Synthesis of 6-Substituted-2,2-dimethyl-2H-1-benzopyrans
Ding, Charles Z.
, p. 4267 - 4273 (2007/10/03)
Various 2,2-dimethyl-6-functional-2H-1-benzopyrans were prepared via a halogen-metal exchange reaction followed by treatment with electrophiles. These 6-functionalized chromenes are important synthetic intermediates for preparation of benzopyran-based pot
