185317-58-2

Upstream product

• 126799-96-0 dimethyl 1-(2-chlorobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate 
• 63777-70-8 2-chlorobenzylazide 

Downstream Products

• 185317-66-2 4,7-Dichloro-1-(2-chloro-benzyl)-1H-[1,2,3]triazolo[4,5-d]pyridazine 
• 185317-60-6 1-(2-Nitrobenzyl)-1H-1,2,3-triazolo-4,5-dicarboxyhydrazide 
• 185317-61-7 1-(2-Chloro-benzyl)-1H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-diol 

Relevant academic research and scientific papers

1,2,3-triazolo [4,5-d] pyridazines-V. Preparation and adenosine receptor binding of new 4-amino derivatives

This paper reports the continuation of studies on the 4-aminosubstituted 1,2,3-triazolo [4,5-d] pyridazine derivatives which had shown binding affinity towards A1-adenosine receptors. 1-Benzyl derivatives bearing new amines and new 1-(substituted benzyl) derivatives were prepared and tested. The biological results showed that some compounds possessed high affinity (~30-70 nM) and good selectivity toward the A1-adenosine receptors. Further information about structure-biological activity relationships was acquired.