185319-20-4

Basic information

• Product Name: 1-(2,6-dichloropyridin-4-yl)ethanone
• Synonyms: 1-(2,6-dichloropyridin-4-yl)ethanone
• CAS NO: 185319-20-4
• Molecular Formula: C7H5Cl2NO
• Molecular Weight: 190.0267
• Mol File: 185319-20-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1-(2,6-dichloropyridin-4-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-dichloropyridin-4-yl)ethanone(185319-20-4)
• EPA Substance Registry System: 1-(2,6-dichloropyridin-4-yl)ethanone(185319-20-4)

Safety Data

• Hazardous Substances Data: 185319-20-4(Hazardous Substances Data)

Usage

General Description

1-(2,6-dichloropyridin-4-yl)ethanone is a chemical compound that belongs to the class of pyridyl ketones. Its molecular formula is C7H5Cl2NO, and it has a molecular weight of 189.03 g/mol. 1-(2,6-dichloropyridin-4-yl)ethanone is used in various pharmaceutical and chemical applications, particularly as an intermediate in the synthesis of other compounds. It is also used as a building block in organic synthesis and as a reagent in chemical reactions. The dichloropyridinyl group in the molecule makes it useful in the development of new drugs and agrochemicals. This chemical can be hazardous if not handled properly and should be used in a controlled environment by trained personnel.

Upstream product

• 848498-98-6 2,6-dichloro-N-methyl-N-(methyloxy)-4-pyridinecarboxamide 
• 917-54-4 methyllithium 
• 183433-63-8 2,6-dichloro-4-(2-ethyl-1,3-dioxolan-2-yl)pyridine 
• 183433-62-7 1-(2,6-dichloropyridin-4-yl)propan-1-one 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1187669-40-4 4-(2,6-dichloro-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine 

Relevant articles and documents

Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors

A series of novel isocombretapyridines were designed and synthesized based on a lead compound isocombretastatin A-4 (isoCA-4) by replacing 3,4,5-trimethoxylphenyl with substituent pyridine nucleus. The MTT assay results showed that compound 20a possessed the most potent activities against all tested cell lines with IC50 values at nanomolar concentration ranges. Moreover, 20a inhibited tubulin polymerization at a micromolar level and also displayed potent anti-vascular activity in vitro. Further mechanistic studies were conducted to demonstrate that compound 20a could bind to the colchicine site of tubulin,and disrupte the cell microtubule networks, induce G2/M phase arrest, promote apoptosis and depolarize mitochondria of K562 cells in a dose-dependent manner. Notably, 20a exhibited more potent tumor growth inhibition activity with 68.7% tumor growth inhibition than that of isoCA-4 in H22 allograft mouse model without apparent toxicity. The present results suggested that compound 20a may serve as a promising potent microtubule-destabilizing agent candidate for the development of therapeutics to treat cancer.

POTASSIUM CHANNEL MODULATORS

Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with potassium channels.

AMINOPYRAZINE DERIVATIVE AND MEDICINE

The present invention relates to a compound represented by general formula [1] satisfying the following (I) or (II), or a pharmaceutical acceptable salt of the compound. (I) X is CH or N; R1 is a halogen atom,; and R2 is H, a halogen atom, CN, [2], [3], [8], [9], an —O-alkyl, an —O-(saturated ring), etc. [2]: —C(RC)(RD)(RE) (RC to RE each are H, an alkyl, etc.) [3]: —N(RF)(RG) (RF and RG each are H, OH, amino, a (hetero)aryl, etc.) [8]: —C(═O)RL (RL is an alkyl, OH, an alkoxy, amino, etc.) [9]: a (substituted)phenyl; (II) X is >C—C(—O)R3 (R3 is a (substituted)amino, an alkoxy, OH, etc.); R1 is a halogen atom; R2 is H; R3 is H or OH; and R3 and R4 each are H or an alkyl.