185329-90-2Relevant academic research and scientific papers
Thiophenesulfonamides as endothelin receptor antagonists
Raju,Wu, Chengde,Kois, Adam,Verner, Erik,Okun, Ilya,Stavros, Fiona,Chan, Ming Fai
, p. 2651 - 2656 (2007/10/03)
The synthesis and in vitro binding affinities of a series of thiophenesulfonamides as ET(A) selective endothelin receptor antagonists is described. The most potent inhibitor displayed an IC50 of 43 nM and 3 μM to ET(A) and ET(B) receptors, respectively.
