185376-75-4

Upstream product

• 100306-33-0 (1R)-3-chloro-1-phenylpropanol 
• 100-46-9 benzylamine 
• 27152-63-2 3-(N-Benzylamino)-1-phenylpropan-1-on 

Downstream Products

• 185376-71-0 2-[Benzyl-((R)-3-hydroxy-3-phenyl-propyl)-amino]-1-phenyl-ethanone 
• 215391-90-5 3-[Benzyl-((R)-3-hydroxy-3-phenyl-propyl)-amino]-1-phenyl-propan-1-one 
• 1316850-18-6 (R)-3-(benzo[d]thiazol-2-ylamino)-1-phenylpropan-1-ol 
• 1316850-19-7 4-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine 
• 138750-31-9 (1R)-3-amino-1-phenyl-1-propanol 

Relevant academic research and scientific papers

Asymmetric Hydrogenation of β-Secondary Amino Ketones Catalyzed by a Ruthenocenyl Phosphino-oxazoline-ruthenium Complex (RuPHOX-Ru): The Synthesis of γ-Secondary Amino Alcohols

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX-Ru) was applied successfully to the asymmetric hydrogenation of β-secondary amino ketones, directly affording the corresponding chiral γ-secondary amino alcohols in up to 99% yield and with 99% ee. Reaction with β-(benzylamino)-1-phenylpropan-1-one could be performed on a gram-scale with a relatively low catalyst loading (up to 2000 S/C). The resulting hydrogenated product could be used for the synthesis of synthetically useful compounds.

Stereocontrol between remote atom centers in acyclic substrates. Anti addition of hydride to 1,5-, 1,6-, and 1,7-hydroxy ketones

For conformationally unconstrained, acyclic organic compounds, the control of stereogenic centers at remote positions of a chain, that is, at a distance of four or more atom centers, remains a challenging problem in asymmetric synthesis. We report on our