185377-97-3Relevant articles and documents
Rationally designed inhibitors of inosine monophosphate dehydrogenase
Zhang, Han-Zhong,Rao, Kotesvar,Carr, Stephen F.,Papp, Eva,Straub, Kenneth,Wu, John C.,Fried, Josef
, p. 4 - 8 (2007/10/03)
Functionalized 2-alkyl derivatives of inosinic acid have been synthesized to serve as reversible as well as irreversible inhibitors of the human type II enzyme inosine monophosphate dehydrogenase. These compounds were designed to react with Cys-331 of the