185385-14-2Relevant academic research and scientific papers
Anodic modification of proline derivatives using a lithium perchlorate/nitromethane electrolyte solution.
Kim, Shokaku,Hayashi, Kanako,Kitano, Yoshikazu,Tada, Masahiro,Chiba, Kazuhiro
, p. 3735 - 3737 (2007/10/03)
[reaction: see text] N-Acyliminium cation of prolines was efficiently generated to accumulate in an undivided cell at 0 degrees C by an anodic oxidation of N-acylprolines or alpha'-phenylsulfanylated N-acylproline derivatives in a lithium perchlorate/nitr
New synthetic method of optically active α-methylproline and α-methylpipecolinic acid using electrochemical oxidation as a key reaction
Matsumura, Yoshihiro,Kinoshita, Toshio,Yanagihara, Yuka,Kanemoto, Noriko,Watanabe, Mitsuaki
, p. 8395 - 8398 (2007/10/03)
A new method for the stereoselective α-methylation of N-protected L-proline and L-pipecolinic acid esters is presented. The method consisted of electrochemical α'-methoxylation of the α-amino acid derivatives, the replacement of the α'-methoxy group with a phenylthio group, α-methylation, and reductive removal of the α'-phenylthio group, successively. The intermediates in this method could be used for the preparation of optically active acyclic α-methylated α-amino acids.
