185385-16-4Relevant academic research and scientific papers
New synthetic method of optically active α-methylproline and α-methylpipecolinic acid using electrochemical oxidation as a key reaction
Matsumura, Yoshihiro,Kinoshita, Toshio,Yanagihara, Yuka,Kanemoto, Noriko,Watanabe, Mitsuaki
, p. 8395 - 8398 (1996)
A new method for the stereoselective α-methylation of N-protected L-proline and L-pipecolinic acid esters is presented. The method consisted of electrochemical α'-methoxylation of the α-amino acid derivatives, the replacement of the α'-methoxy group with a phenylthio group, α-methylation, and reductive removal of the α'-phenylthio group, successively. The intermediates in this method could be used for the preparation of optically active acyclic α-methylated α-amino acids.
