185409-83-0

Upstream product

• 85116-37-6 (-)-diisopinocamphenylborane chloride 
• 185409-68-1 (S)-5-benzyloxy-3-(triethylsiloxy)pentanal 
• 185409-75-0 (4S,6S)-8-benzyloxy-4-(tert-butyldimethylsiloxy)-6-(triethylsiloxy)-2-octanone 
• 185409-77-2 C₄₇H₈₃BO₄Si₂ 

Downstream Products

• 185409-87-4 (2S,4S,6R,8S,10S)-2,8-bis-(2-benzyloxy-ethyl)-10-(tert-butyl-dimethyl-silanyloxy)-1,7-dioxa-spiro[5.5]undecan-4-ol 
• 185409-89-6 (2S,4S,6R,8S,10S)-2,8-Bis-(2-benzyloxy-ethyl)-10-(tert-butyl-dimethyl-silanyloxy)-4-methyl-1,7-dioxa-spiro[5.5]undecan-4-ol 

Relevant academic research and scientific papers

Studies in marine macrolide synthesis: Stereocontrolled synthesis of the AB-spiroacetal subunit of spongistatin 1 (altohyrtin A)

The C1-C13 subunit 2, containing the AB-spiroacetal ring system of spongistatin 1 (1), was prepared in 11 steps with 90% ds from 3-benzyloxypropanal. Key steps include (i) the aldol reaction between 4 and 11 using (-)-Ipc2

Synthetic spiroketal pyranes as potent anti-cancer agents

Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds are adapted to interact favorably with a novel SP binding pocket on tubulin, which pocket is useful for screening of anti-tubulin, anti-proliferation, and anti-cancer drugs.