185411-82-9Relevant academic research and scientific papers
Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1'-substituted analogs
Yamada, Akira,Hattori, Kouji,Kuroda, Satoru,Chiba, Toshiyuki,Kamimura, Toshiaki,Sakane, Kazuo
, p. 2705 - 2708 (1996)
The synthesis, antibacterial activity and DHP-susceptibility of a series of novel 2-vinyl carbapenems is described. Carbapenems having a 1'-substituted vinyl moiety at the 2 position were found to be very stable toward DHP-1, displaying comparable stability to compounds with a 1β-methyl functionality.
