Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1'-substituted analogs

DOI: 10.1016/S0960-894X(96)00495-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2705 - 2708 (1996)

Update date:2022-08-05

Topics:

Authors:

Yamada, Akira

Hattori, Kouji

Kuroda, Satoru

Chiba, Toshiyuki

Kamimura, Toshiaki

Sakane, Kazuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(96)00495-7

The synthesis, antibacterial activity and DHP-susceptibility of a series of novel 2-vinyl carbapenems is described. Carbapenems having a 1'-substituted vinyl moiety at the 2 position were found to be very stable toward DHP-1, displaying comparable stability to compounds with a 1β-methyl functionality.

Full text of DOI:10.1016/S0960-894X(96)00495-7

Products guided by the article

Product name:(S)-2-((R)-4-{(2R,3S)-1-[Allyloxycarbonyl-(triphenyl-λ⁵-phosphanylidene)-methyl]-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-1-hydroxy-3-oxo-pentyl)-pyrrolidine-1-carboxylic acid allyl ester

Cas No:185411-82-9

R&D Labs maybe for 185411-82-9

Global United Biotechnology Inc.

Contact:+86-21-61618568

Address:Room 309, Building 6, NO.135, Jinyu Road, Pudong
HAINAN JINYING IMPORT AND EXPORT CO. LTD

Contact:+86-898-32875423

Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Aminodiscovery Co.,Ltd.

Contact:+86-535-8888888

Address:No.161 Haishi Rd.
Hangzhou Dingyan Chem Co., Ltd

website:http://www.dingyanchem.com

Contact:86-571-87157530

Address:RM.1118,NO.1 Building, Baiyun Tower,Jianggan Area, Hangzhou city, China,310004
Baoding City Light Industry And Textiles Imp.& Exp. Corp. Chemical Department.

Contact:86-312-3262436

Address:NO.658 CHAOYANG SOUTH STREET,BAODING CITY HEBEI CHINA

Relevant to this article

Mixed iron-silicon-tin complexes stabilized by a phosphinoenolate bridging ligand. Crystal structure of [(OC)₃{(MeO)₃Si}-Fe{μ-Ph ₂PCH=C(O)Ph}SnBuⁿ₂]

Doi:10.1039/DT9960004365
(1996)
Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)- Arg-Gly-Arg tripeptide sequence

Doi:10.1016/S0960-894X(99)00582-X
(2000)
Efficient asymmetric synthesis of (R)-3-hydroxy- and alkanoyloxytetradecanoic acids and method for the determination of enantiomeric purity

Doi:10.1016/S0957-4166(96)00464-8
(1996)
Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone derivatives

Doi:10.3987/COM-99-8689
(2000)
Sunlight-Driven Synthesis of Triarylethylenes (TAEs) via Metal-Free Mizoroki–Heck-Type Coupling

Doi:10.1002/ejoc.201800883
(2018)
Doi:10.1007/BF00848993
()

Article Doi