Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1'-substituted analogs

DOI: 10.1016/S0960-894X(96)00495-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2705 - 2708 (1996)

Update date:2022-08-05

Topics:

Authors:

Yamada, Akira

Hattori, Kouji

Kuroda, Satoru

Chiba, Toshiyuki

Kamimura, Toshiaki

Sakane, Kazuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(96)00495-7

The synthesis, antibacterial activity and DHP-susceptibility of a series of novel 2-vinyl carbapenems is described. Carbapenems having a 1'-substituted vinyl moiety at the 2 position were found to be very stable toward DHP-1, displaying comparable stability to compounds with a 1β-methyl functionality.

Full text of DOI:10.1016/S0960-894X(96)00495-7

Products guided by the article

Product name:(S)-2-((R)-4-{(2R,3S)-1-[Allyloxycarbonyl-(triphenyl-λ⁵-phosphanylidene)-methyl]-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-1-hydroxy-3-oxo-pentyl)-pyrrolidine-1-carboxylic acid allyl ester

Cas No:185411-82-9

R&D Labs maybe for 185411-82-9

Shanghai Hope Chem Co., Ltd

website:http://www.hope-chem.com

Contact:86-21-58090396-805

Address:Floor 4, Building 5, No.588 Tianxiong Road, Zhoupu International Medical Zone, ShangHai, China
Shanghai Biobond Pharmaceutical Co.,Ltd

website:http://www.sh-biobond.com/EnglishIndex.aspx

Contact:021-68719686 /18939786273/ 18917373795

Address:Shanghai Zhangjiang
ANHUI WEICHI CHEMICAL CO.,LTD

website:http://www.weichichem.com

Contact:+8613912949432

Address:Fine Chemical Industrial Base,Wujiang town,He County,Anhui China.
Lyrin Industrial Corporation Limited

Contact:86-731-82571800

Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Qingdao XinYongAn Chemicals Co., Ltd

Contact:+86-532-81107967

Address:Chengyang dual-port industrial park by the sea，Qingdao

Relevant to this article

Mixed iron-silicon-tin complexes stabilized by a phosphinoenolate bridging ligand. Crystal structure of [(OC)₃{(MeO)₃Si}-Fe{μ-Ph ₂PCH=C(O)Ph}SnBuⁿ₂]

Doi:10.1039/DT9960004365
(1996)
Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)- Arg-Gly-Arg tripeptide sequence

Doi:10.1016/S0960-894X(99)00582-X
(2000)
Efficient asymmetric synthesis of (R)-3-hydroxy- and alkanoyloxytetradecanoic acids and method for the determination of enantiomeric purity

Doi:10.1016/S0957-4166(96)00464-8
(1996)
Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone derivatives

Doi:10.3987/COM-99-8689
(2000)
Sunlight-Driven Synthesis of Triarylethylenes (TAEs) via Metal-Free Mizoroki–Heck-Type Coupling

Doi:10.1002/ejoc.201800883
(2018)
Doi:10.1007/BF00848993
()

Article Doi