Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1'-substituted analogs

DOI: 10.1016/S0960-894X(96)00495-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2705 - 2708 (1996)

Update date:2022-08-05

Topics:

Authors:

Yamada, Akira

Hattori, Kouji

Kuroda, Satoru

Chiba, Toshiyuki

Kamimura, Toshiaki

Sakane, Kazuo

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Article abstract of DOI:10.1016/S0960-894X(96)00495-7

The synthesis, antibacterial activity and DHP-susceptibility of a series of novel 2-vinyl carbapenems is described. Carbapenems having a 1'-substituted vinyl moiety at the 2 position were found to be very stable toward DHP-1, displaying comparable stability to compounds with a 1β-methyl functionality.

Full text of DOI:10.1016/S0960-894X(96)00495-7

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