185434-58-6

Basic information

• Product Name: 4-Piperidineacetic acid, 1-[(4-nitrophenyl)methyl]-, ethyl ester
• CAS NO: 185434-58-6
• Molecular Formula: C16H22N2O4
• Molecular Weight: 306.362
• Mol File: 185434-58-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Piperidineacetic acid, 1-[(4-nitrophenyl)methyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidineacetic acid, 1-[(4-nitrophenyl)methyl]-, ethyl ester(185434-58-6)
• EPA Substance Registry System: 4-Piperidineacetic acid, 1-[(4-nitrophenyl)methyl]-, ethyl ester(185434-58-6)

Safety Data

• Hazardous Substances Data: 185434-58-6(Hazardous Substances Data)

Upstream product

• 102879-50-5 ethyl 4-pyridylacetate hydrochloride 
• 141945-70-2 1-(4-nitrobenzyl)-4-piperidone 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 41661-47-6 piperidin-4-one 
• 555-16-8 4-nitrobenzaldehdye 
• 617714-38-2 [1-(4-nitro-benzyl)-piperidin-4-ylidene]-acetic acid ethyl ester 

Downstream Products

• 617714-48-4 3-methyl-1-[1-(4-nitro-benzyl)-piperidin-4-yl]-butan-2-one 
• 617714-50-8 2-methyl-1-[1-(4-nitro-benzyl)-piperidin-4-ylmethyl]-propylamine 
• 185434-24-6 4-(2-Benzhydryloxy-ethyl)-1-(4-nitro-benzyl)-piperidine 
• 185434-26-8 4-[2-(diphenylmethoxy)ethyl]-1-[(4-aminophenyl)methyl]piperidine 
• 617714-45-1 3-methyl-1-[1-(4-nitro-benzyl)-piperidin-4-yl]-butan-2-ol 
• 185434-60-0 2-[1-(4-Nitro-benzyl)-piperidin-4-yl]-ethanol 

Relevant articles and documents

Design and synthesis of novel CCR3 antagonists

As part of our investigation into the development of potent CCR3 antagonists, a series of piperidine analogues was designed and prepared. Exploration of the piperidine core examined both the basicity and the location of a nitrogen, as well as conformational variants. The bicyclo-piperidine 24c was found to be the most potent inhibitor of CCR3 with an IC50 of 0.0082 μM in the binding assay and 0.0024 μM in the chemotaxis assay.