185435-29-4

Upstream product

• 88-17-5 2-(trifluoromethyl)benzenamine 
• 13114-85-7 1-<2-(trifluoromethyl)phenyl>urea 
• 105-53-3 diethyl malonate 

Downstream Products

• 1566577-65-8 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-57-8 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-89-6 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-81-8 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-morpholinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-73-8 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-49-8 (E)-5-((dimethylamino)methylene)-1-(2-(trifluoromethyl)phenyl)pyrimidine-2,4,6-trione 
• 185435-44-3 3-(2-{[(tert-butyldimethylsilyl)oxy][²H₂]methyl}phenyl)-10-(4-tert-butylphenyl)[5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione 
• 1026501-87-0 C₂₈H₂₄⁽²⁾H₃N₃O₃ 
• 185435-45-4 10-(4-tert-butylphenyl)-3-[2-(trifluoromethyl)phenyl][5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione 
• 185435-32-9 2-[10-(4-tert-Butyl-phenyl)-2,4-dioxo-4,10-dihydro-2H-pyrimido[4,5-b]quinolin-3-yl]-benzoic acid 
• 185435-31-8 6-(4-tert-Butyl-phenylamino)-3-(2-trifluoromethyl-phenyl)-1H-pyrimidine-2,4-dione 
• 161744-26-9 10-(4-tert-butylphenyl)-3-<2-(hydroxymethyl)phenyl>pyrimido<4,5-b>quinoline-2,4(3H,10H)-dione 
• 161744-28-1 10-(4-tert-butylphenyl)-3-<2-(trifluoromethyl)phenyl>pyrimido<4,5-b>quinoline-2,4(3H,10H)-dione 
• 161744-27-0 10-(4-tert-butylphenyl)-1,5-dihydro-3-<2-(hydroxymethyl)phenyl>pyrimido<4,5-b>quinoline-2,4(3H,10H)-dione 

Relevant academic research and scientific papers

Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors

A series of novel quinoline derivatives bearing 5-(aminomethylene) pyrimidine-2,4,6-trione moiety were designed, synthesized, and evaluated for their c-Met kinase inhibitory activities and antiproliferative activities against 5 cancer cell lines (HT-29, H460, MKN-45, A549, and U87MG) in vitro. Most compounds showed moderate to excellent potency, with the most promising analogue 45 (c-Met half-maximal inhibitory concentration [IC50] = 1.15 nM) showing high selectivity versus 5 other tyrosine kinases, VEGFR-2, Flt-3, PDGFR-β, c-Kit, and EGFR. Structure-activity relationship studies indicated that electron-donating groups on the phenyl ring at the 3-position of pyrimidine-2,4,6-trione were required to increase the electron density on the 5-(aminomethylene)pyrimidine-2,4,6-trione moiety.

Atropisomeric flavoenzyme models with a modified pyrimidine ring: Syntheses, physical properties, and stereochemistry, in the reactions with NAD(P)H analogs

Optically active 5-deazaflavin derivatives (3-aryl-10-(4-tert-butylphenyl)pyrimido[4,5-b]quinoline-2,4(3H,10H)-di one) with an axial chirality at the pyrimidine ring have been synthesized, and the kinetics of enantiomerization have been measured for some