185448-73-1 Usage
Uses
Used in Pharmaceutical and Agrochemical Synthesis:
2-Chloro-3',4'-bis(pivaloyloxy)acetophenone is employed as a precursor in the production of pharmaceuticals and agrochemicals. Its unique structure allows for the creation of a wide range of bioactive compounds, contributing to the development of new drugs and pesticides.
Used in Organic Chemistry as a Reagent:
In the field of organic chemistry, 2-Chloro-3',4'-bis(pivaloyloxy)acetophenone is used as a reagent for the introduction of the pivaloyloxy group into various molecules. This group modification can enhance the stability, solubility, or reactivity of target compounds, facilitating the synthesis of complex organic molecules.
Used in Material Science for Polymer and Coating Production:
2-Chloro-3',4'-bis(pivaloyloxy)acetophenone also has potential applications in material science, particularly in the development of polymers and coatings. Its incorporation into these materials can impart specific properties, such as improved durability, resistance, or adhesion.
Safety Precautions:
Due to the reactivity of 2-Chloro-3',4'-bis(pivaloyloxy)acetophenone and potential health hazards associated with its use, it is crucial to follow proper safety protocols when handling and working with this chemical. This includes the use of appropriate personal protective equipment, working in well-ventilated areas, and adhering to established safety guidelines to minimize risks.
Check Digit Verification of cas no
The CAS Registry Mumber 185448-73-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,4,4 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 185448-73:
(8*1)+(7*8)+(6*5)+(5*4)+(4*4)+(3*8)+(2*7)+(1*3)=171
171 % 10 = 1
So 185448-73-1 is a valid CAS Registry Number.
185448-73-1Relevant academic research and scientific papers
Gill,Freeman,Irwin,Wilson
, p. 847 - 859 (1996)
The soft-drug 1 (R = Me, Et) and pro-soft-drug 3 have been prepared as models of topical anti-psoriatic β-adrenergic agonists. The chemical hydrolysis of 3 proceeded via the acid 18 with a maximum stability at apparent pH ~4.0. In the presence of PLCE, the required metabolism of 3 to the soft-drug 1 (R = Et) was achieved, which slowly degraded to the dihydroxy acid 2. Soft-drug 1 (R = Et) was poorly transported across a silicone membrane, whereas the pro-soft-drug 3 was more efficient and the rate increased over the donor apparent pH range 3-8. Soft-drug 1 (R = Et) was a full β-agonist on the guinea-pig tracheal preparation, whereas the pro-soft-drug 3 produced only slowly developing responses at high concentrations (> 10 μM).
