185461-70-5

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 185461-68-1 (3S,4R,5S)-4-{(2S,3R)-3-Benzyloxy-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-butyrylamino}-3-hydroxy-5-methyl-heptanoic acid 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 185461-66-9 (3S,4R,5S)-4-{(2S,3R)-3-Benzyloxy-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-butyrylamino}-3-hydroxy-5-methyl-heptanoic acid methyl ester 
• 1053706-34-5 (3S,4R,5S)-4-((2S,3R)-2-Amino-3-benzyloxy-butyrylamino)-3-hydroxy-5-methyl-heptanoic acid methyl ester 
• 159407-38-2 (3S,4R,5S)-Boc-isostatine methyl ester 
• 185461-64-7 (3S,4R,5S)-4-((2S,3R)-3-Benzyloxy-2-tert-butoxycarbonylamino-butyrylamino)-3-hydroxy-5-methyl-heptanoic acid methyl ester 

Downstream Products

• 118171-87-2 Boc-(R)-MeLeu-(S)-Thr(Bzl)-(3S,4R,5S)-Ist(TBDMS)-OTce 
• 118171-89-4 Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH 
• 118206-77-2 Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OTce 
• 185461-50-1 cyclo-[N(Me)-O(Me)-Tyr-O-[Boc-(R)-N(Me)-Leu->-Thr-Ist(TBDMS)-Hip-Leu-Pro-> 
• 137219-37-5 dehydrodidemnin B 
• 185461-54-5 Boc-(R)-N(Me)-Leu-Thr[Z-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OH 
• 185461-53-4 Boc-(R)-N(Me)-Leu-Thr[Z-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OTce 
• 185461-55-6 Boc-(R)-N(Me)-Leu-Thr[H-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OH 

Relevant academic research and scientific papers

Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution

New total syntheses of didemnin A and of dehydrodidemnin B are described. The latter didemnin has the highest antiproliferative activity of all members of this family of macrocyclic depsipeptides. It was produced on coupling the side chain Pyr-Pro-OH to d