185516-79-4Relevant academic research and scientific papers
Nitroalkanes as a new source of 2-alkylidene-1,4-diols, in two steps
Ballini, Roberto,Bosica, Giovanna,Damiani, Marco,Righi, Paolo
, p. 13451 - 13456 (2007/10/03)
A variety of 2-alkylidene-1,4-diols have been conveniently prepared, in two steps, by conjugate addition of a nitroalkane to the appropriate enedione derivatives under basic conditions (DBU), followed by chemoselective reduction (LiAlH4/Et2O) of the carbonyl functionalities of the Michael adduct, obtained after elimination of nitrous acid.
A new two-step synthesis of 2-alkylated 1,4-diketones and α-alkylated γ-keto esters
Ballini,Bosica,Petrelli,Petrini
, p. 1236 - 1240 (2007/10/03)
2-Alkylated 1,4-diketones and α-alkylated γ-keto esters can be easily prepared by a two-step procedure which involves first the conjugate addition of a nitroalkane to an enedione derivative in acetonitrile with DBU as base, followed by chemoselective hydrogenation of the C-C double bond (H2 10% Pd/C) of the Michael adduct, obtained after elimination of nitrous acid.
