2833-24-1Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF ALKYL 5- (DICARBOXIMIDO) LEVULINATE AND ALKYL 4-OXO-PENTENOATE
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Page/Page column 6-7, (2008/06/13)
A method of manufacturing esters of dicarboxyimidolevulinic acid and alkyl trans-4-oxo-2-pentenoate. This method includes two reaction steps, wherein the first step of said two reaction steps is a bromination of alkyl-levulinate, to obtain alkyl-(3 and 5)-bromolevulinate, and the second step of said two reaction steps is a synthesis of esters of dicarboxyimidolevulinic acid and alkyl trans-4-oxo-2-pentenoate, by reacting the alkyl-(3 and 5)-bromolevulinate obtained in said first step with dicarboxyimide anion.
A Flexible and Efficient Synthesis of Methyl 4-Oxo-2-alkenoates
Reichelt, Ingrid,Reissig, Hans-Ulrich
, p. 820 - 827 (2007/10/02)
The title compounds E are obtained in good yield by low temperature ring cleavage of the easily available methyl 2-siloxycyclopropanecarboxylates C with bromine and subsequent elimination of hydrogen bromide.Due to the variability of C a high flexibility concerning substituents R1 - R4 in products E is guaranteed. 2-Alkyl- and 2-methylthio-substituted olefins are thus effectively synthesized.In several cases the initially formed methyl 2-bromo-4-oxoalkanoates F are stable enough to be isolated in high yield.
