185525-88-6

Basic information

• Product Name: N-[1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]carbamic acid 1,1-dimethylethyl ester
• Synonyms: N-[1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]carbamic acid 1,1-dimethylethyl ester
• CAS NO: 185525-88-6
• Molecular Weight: 464.605
• Mol File: 185525-88-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]carbamic acid 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]carbamic acid 1,1-dimethylethyl ester(185525-88-6)
• EPA Substance Registry System: N-[1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]carbamic acid 1,1-dimethylethyl ester(185525-88-6)

Safety Data

• Hazardous Substances Data: 185525-88-6(Hazardous Substances Data)

Upstream product

• 47173-80-8 N-Boc-D-serine(Bzl)-OH 
• 96651-85-3 2,3-dihydrospiro[1H-indene-1,4'-piperidine] hydrochloride 
• 148835-99-8 N-Boc spiroindane 
• 428-38-6 2,3-dihydrospiro[1H-indene-1,4'-piperidine] 

Downstream Products

• 185526-02-7 C₃₃H₄₅N₃O₅ 
• 185525-90-0 C₃₂H₄₃N₃O₅ 
• 185525-89-7 1'-[[2(R)-amino-1-oxo-3-(phenylmethyloxy)]propyl]-2,3-dihydrospiro[1H-indene-1,4'-piperidine] 

Relevant articles and documents

Synthesis and biological activities of spiroheterocyclic growth hormone secretagogues

The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replaced with spirobenzodihydrothiophen derivatives to enhance not only in vitro potency but also oral activity. In this study non- aromatic D-2-amino-4-cyclohexylbutanoic analogs (8a-8d) were also identified to be active secretagogues.

Peptidomimetic growth hormone secretagogues: Synthesis and biological activities of analogs varied at the indole nucleus of the prototypical spiropiperidine L-162,752

SAR studies around the indole nucleus of the prototypical peptidomimetic L-162,752 revealed that the D-Trp could be replaced with 3-phenylpropyl-D-glycine and O-benzyl-D-serine to provide secretagogues with comparable intrinsic activity but with significantly better oral activity in dogs. Use of dimethyl β-alanine amino side-chains led to a considerable loss of activity in the D-homophenylalanine and O-benzyl-D-serine series.