185525-91-1Relevant academic research and scientific papers
Peptidomimetic growth hormone secretagogues: Synthesis and biological activities of analogs varied at the indole nucleus of the prototypical spiropiperidine L-162,752
Nargund, Ravi P.,Chen, Meng-Hsin,Johnston, David B. R.,Barakat, Khaled J.,Tata, James R.,Cheng, Kang,Jacks, Thomas M.,Chan, Wanda W. -S,Wei, Liente,Butler, Bridget R.,Hickey, Gerard J.,Smith, Roy G.,Patchett, Arthur A.
, p. 1731 - 1736 (1996)
SAR studies around the indole nucleus of the prototypical peptidomimetic L-162,752 revealed that the D-Trp could be replaced with 3-phenylpropyl-D-glycine and O-benzyl-D-serine to provide secretagogues with comparable intrinsic activity but with significantly better oral activity in dogs. Use of dimethyl β-alanine amino side-chains led to a considerable loss of activity in the D-homophenylalanine and O-benzyl-D-serine series.
Spiro piperidines and homologs promote release of growth hormone
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, (2008/06/13)
There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such spiro compounds as the active ingredient thereof are also disclosed.
