185525-93-3Relevant academic research and scientific papers
Peptidomimetic growth hormone secretagogues: Synthesis and biological activities of analogs varied at the indole nucleus of the prototypical spiropiperidine L-162,752
Nargund, Ravi P.,Chen, Meng-Hsin,Johnston, David B. R.,Barakat, Khaled J.,Tata, James R.,Cheng, Kang,Jacks, Thomas M.,Chan, Wanda W. -S,Wei, Liente,Butler, Bridget R.,Hickey, Gerard J.,Smith, Roy G.,Patchett, Arthur A.
, p. 1731 - 1736 (2007/10/03)
SAR studies around the indole nucleus of the prototypical peptidomimetic L-162,752 revealed that the D-Trp could be replaced with 3-phenylpropyl-D-glycine and O-benzyl-D-serine to provide secretagogues with comparable intrinsic activity but with significantly better oral activity in dogs. Use of dimethyl β-alanine amino side-chains led to a considerable loss of activity in the D-homophenylalanine and O-benzyl-D-serine series.
