185526-32-3

Basic information

• Product Name: 4'-N-BOC-SPIRO-INDANE-PIPERIDINE-3-CARBOXYLIC ACID
• Synonyms: 4'-N-BOC-SPIRO-INDANE-PIPERIDINE-3-CARBOXYLIC ACID;1'-(TERT-BUTOXYCARBONYL)-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-3-CARBOXYLIC ACID;Spiro[1H-indene-1,4'-piperidine]-1',3-dicarboxylic acid, 2,3-dihydro- 1,1-diMethyl ethyl ester;1'-(tert-butoxycarbonyl)spiro[indene-1,4'-piperidine]-3-carboxylic acid;Spiro[1H-indene-1,4'-piperidine]-1',3-dicarboxylic acid, 2,3-dihydro-, 1'-(1,1-diMethylethyl) ester;1'-[(2-methylpropan-2-yl)oxycarbonyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-carboxylic acid;1′-Boc-2,3-dihydrospiro[indene-1,4′-piperidine]-3-carboxylic acid
• CAS NO: 185526-32-3
• Molecular Formula: C19H25NO4
• Molecular Weight: 331.42
• Mol File: 185526-32-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4'-N-BOC-SPIRO-INDANE-PIPERIDINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-N-BOC-SPIRO-INDANE-PIPERIDINE-3-CARBOXYLIC ACID(185526-32-3)
• EPA Substance Registry System: 4'-N-BOC-SPIRO-INDANE-PIPERIDINE-3-CARBOXYLIC ACID(185526-32-3)

Safety Data

• Hazardous Substances Data: 185526-32-3(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
4'-N-BOC-SPIRO-INDANE-PIPERIDINE-3-CARBOXYLIC ACID is used as a building block or intermediate in the synthesis of pharmaceutical compounds due to its ability to participate in esterification and amidation reactions, which are crucial for creating diverse drug molecules.
Used in Organic Synthesis:
In the field of organic synthesis, 4'-N-BOC-SPIRO-INDANE-PIPERIDINE-3-CARBOXYLIC ACID serves as a key component for constructing complex organic molecules, leveraging its functional groups to facilitate multiple types of chemical reactions.
Used in Material Science:
4'-N-BOC-SPIRO-INDANE-PIPERIDINE-3-CARBOXYLIC ACID is utilized in material science for the development of new materials with specific properties, such as improved stability or reactivity, owing to its distinctive spiro-indane framework and functional groups.

Upstream product

• 201230-82-2 carbon monoxide 
• 185526-14-1 tert-butyl 3-(trifluoromethylsulfonyloxy)spiro[indene-1,4'-piperidine]-1-carboxylate 

Downstream Products

• 185526-66-3 1'-[(1,1-dimethylethoxy)carbonyl]-2,3-dihydrospiro[1H-indene-1,4'-piperidine]-3-acetic acid 

Relevant articles and documents

The design and synthesis of orally active short duration spiroindane growth hormone secretagogues

The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily metabolized ester into the spiroindane benzylic position provided a series of highly potent orally active secretagogues with a short duration of action.

Amido spiropiperidines promote the release of growth hormone

The present invention is directed to certain spiropiperidines of the general structural formula: wherein R1, R2, R3, R3a, R3b, R4and R5are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.