Bioorganic and Medicinal Chemistry Letters p. 2319 - 2324 (1997)
Update date:2022-08-17
Topics:
Tata, James R.
Lu, Zhijian
Jacks, Thomas M.
Schleim, Klaus D.
Cheng, Kang
Wei, Liente
Chan, Wanda W.-S
Butler, Bridget
Tsou, Nancy
Leung, Kwan
Chiu
Hickey, Gerard
Smith, Roy G.
Patchett, Arthur A.
The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily metabolized ester into the spiroindane benzylic position provided a series of highly potent orally active secretagogues with a short duration of action.
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Doi:10.1021/acs.orglett.6b00932
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