185532-47-2

Usage

Uses

Used in Plastics and Polymers Industry:
Benzenesulfonamide, N,N'-1,4-butanediylbis[2,4,6-trimethyl-N-[1-[(2,4,6-trimethylphenyl)sulfonyl]-4-piperidinyl]is used as a stabilizer and UV absorber for improving the durability and performance of plastics and polymers. Its presence helps protect materials from degradation caused by exposure to sunlight and other environmental factors, ensuring a longer lifespan and maintaining the quality of the products.
Used in Industrial and Consumer Products:
Benzenesulfonamide,
N,N'-1,4-butanediylbis[2,4,6-trimethyl-N-[1-[(2,4,6-trimethylphenyl)sulfon
yl]-4-piperidinyl]is also used in the manufacturing of various industrial and consumer products due to its ability to enhance the overall performance and durability of materials. Its application in these products helps maintain their structural integrity and resistance to wear and tear, making them more reliable and long-lasting for end-users.

Upstream product

• 35621-01-3 4-aminopiperidine dihydrochloride 
• 773-64-8 2-mesitylenesulphonyl chloride 
• 628-21-7 1,4-Diiodobutane 
• 185532-45-0 2,4,6-Trimethyl-N-[1-(2,4,6-trimethyl-benzenesulfonyl)-piperidin-4-yl]-benzenesulfonamide 

Relevant academic research and scientific papers

Polyamine analogue regulation of NMDA MK-801 binding: A structure-activity study

A series of analogues and homologues of spermine were synthesized, and their impact on MK-801 binding to the N-methyl-D-aspartate (NMDA) receptor was evaluated. These tetraamines encompass both linear and cyclic compounds. The linear molecules include norspermine, N1,N11-diethylnorspermine, N1,N12-bis(2,2,2-trifluoroethyl)spermine, homospermine, and N1,N14-diethylhomospermine. The cyclic tetraamines consist of the piperidine analogues N1,N3-bis(4-piperidinyl)-1,3-diaminopropane, N1,N4-bis(4-piperidinyl)-1,4-diaminobutane, N1,N4-bis(4-piperidinylmethyl)-1,4-diaminobutane, and N1,N4-bis[2-(4-piperidinyl)ethyl]-1,4-diaminobutane and the pyridine analogues N1,N3-bis(4-pyridyl)-1,3-diaminopropane, N1,N4-bis(4-pyridyl)-1,4-diaminobutane, N1,N4-bis(4-pyridylmethyl)-1,4-diaminobutane, and N1,N4-bis[2-(4-pyridyl)-ethyl]-1,4-diaminobutane. This structure-activity set makes it possible to establish the importance of charge, intercharge distance, and terminal nitrogen substitution on polyamine-regulated MK-801 binding in the NMDA channel. Four families of tetraamines are included in this set: norspermines, spermines, homospermines, and tetraazaoctadecanes. Calculations employing a SYBYL modeling program revealed that the distance between terminal nitrogens ranges between 12.62 and 19.61 ?. The tetraamines are constructed such that within families cyclics and acyclics have similar lengths but different nitrogen pKa's and thus different protonation, or charge, states at physiological pH. The pKa values for all nitrogens of each molecule and its protonation state at physiological pH are described. The modifications at the terminal nitrogens include introduction of ethyl and β,β,β-trifluoroethyl groups and incorporation into piperidinyl or pyridyl systems. The studies clearly indicate that polyamine length, charge, and terminal nitrogen substitution have a significant effect on how the tetraamine regulates MK-801 binding to the NMDA receptor. Thus a structure-activity basis set on which future design of MK-801 agonists and antagonists can be based is now available.