185548-35-0Relevant academic research and scientific papers
Discovery of a new efficient chiral ligand for copper-catalyzed enantioselective Michael additions by high-throughput screening of a parallel library
Chataigner, Isabelle,Gennari, Cesare,Ongeri, Sandrine,Piarulli, Umberto,Ceccarelli, Simona
, p. 2628 - 2634 (2007/10/03)
A combinatorial library of 125 chiral Schiff base ligands 5 was synthesized with the use of solutionphase parallel synthesis and solid-phase extraction (SPE) techniques to scavenge excess reagents and reaction by-products and avoid chromatography. The syn
Discovery of a new efficient chiral ligand for copper-catalyzed enantioselective Michael additions by high-throughput screening of a parallel library
Chataigner, Isabelle,Gennari, Cesare,Piarulli, Umberto,Ceccarelli, Simona
, p. 916 - 918 (2007/10/03)
The optimal ligand 1 for the enantioselective copper-catalyzed 1,4- addition of Et2Zn to cyclic enones [Eq. (1)] was established by multisubstrate (high-throughput) screening of a parallel library of chiral Schiff base ligands. The screening data show how the ligand structure is finely tuned by mutual influences of stereogenic center a (which controls the absolute configuration of the reaction product), stereogenic center b, and the substitution pattern of the aromatic ring.
Hydrogen-bonding donor/acceptor scales in β-sulfonamidopeptides
Gennari, Cesare,Gude, Markus,Potenza, Donatella,Piarulli, Umberto
, p. 1924 - 1931 (2007/10/03)
The conformational preferences of β-sulfonamidopeptides in chloroform solution were investigated by variable-temperature 1H NMR spectroscopy and FT-IR spectroscopy. The following hydrogen-bonding acceptor scale was derived from the experiments:
A new method for the solution and solid phase synthesis of chiral β-sulfonopeptides under mild conditions
Gude, Markus,Piarulli, Umberto,Potenza, Donatella,Salom, Barbara,Gennari, Cesare
, p. 8589 - 8592 (2007/10/03)
Chiral β-sulfonopeptides were synthesized both in solution and in the solid phase using the sulfonyl chlorides derived from enantiomerically pure 2-substituted taurines under mild coupling conditions [cat. 4-dimethylaminopyridine (DMAP) and excess methyl trimethylsilyl dimethylketene acetal (MTDA) as a proton trap].
