185553-96-2

Basic information

• Product Name: [2'-13C]THYMIDINE
• Synonyms: [2'-13C]THYMIDINE;Thymidine-2'-13C;FINYQPSFLOOCJF-VQEHIDDOSA-N
• CAS NO: 185553-96-2
• Molecular Formula: C10H14N2O5
• Molecular Weight: 243.24
• Mol File: 185553-96-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: [2'-13C]THYMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: [2'-13C]THYMIDINE(185553-96-2)
• EPA Substance Registry System: [2'-13C]THYMIDINE(185553-96-2)

Safety Data

• Hazardous Substances Data: 185553-96-2(Hazardous Substances Data)

Usage

Description

[2'-13C]THYMIDINE, also known as Thymidine-2'-13C, is a labeled version of Thymidine (T412000), which is a constituent of deoxyribonucleic acid (DNA). The presence of the 13C isotope in the 2' position of the thymidine molecule allows for the differentiation of this compound from its non-labeled counterpart in various experimental and analytical techniques.

Uses

Used in Biochemical Research:
[2'-13C]THYMIDINE is used as a tracer for studying the synthesis, incorporation, and metabolism of DNA in biological systems. The 13C labeling enables researchers to track the behavior of this nucleoside within cells and monitor its interactions with other cellular components.
Used in Medical Diagnostics:
[2'-13C]THYMIDINE is used as a diagnostic tool for detecting and monitoring the progression of diseases that involve changes in DNA synthesis, such as cancer. The labeled thymidine can be used to measure the rate of DNA replication in cells, providing valuable information about the aggressiveness and potential treatment response of the disease.
Used in Pharmaceutical Development:
[2'-13C]THYMIDINE is used as a research compound in the development of new drugs targeting DNA synthesis and repair pathways. The labeled thymidine can be employed to study the mechanism of action of potential therapeutic agents and to optimize their efficacy and selectivity.
Used in Radiotracer Studies:
[2'-13C]THYMIDINE is used as a radiotracer in positron emission tomography (PET) and other imaging techniques to visualize and quantify DNA synthesis in vivo. This application can be particularly useful in the study of tumor growth and the evaluation of the effectiveness of cancer treatments.
Used in Forensic Science:
[2'-13C]THYMIDINE can be used as a forensic tool to analyze biological samples, such as blood or tissue, to determine the age of the sample or to identify specific DNA sequences. The 13C labeling provides a unique signature that can be used to distinguish between different sources of DNA.
Used in Environmental Science:
[2'-13C]THYMIDINE can be employed in environmental studies to investigate the impact of pollutants or other environmental factors on the DNA synthesis of microorganisms or other organisms. This information can be used to assess the health of ecosystems and to develop strategies for environmental remediation.

Upstream product

• 65-71-4 thymin 
• 187589-11-3 C₂₁⁽¹³⁾C₅H₂₇⁽²⁾HN₂O₇ 
• 187589-10-2 C₁₈⁽¹³⁾C₅H₂₅⁽²⁾HO₇ 
• 187589-09-9 C₁₀⁽¹³⁾C₅H₁₉⁽²⁾HO₅ 
• 159496-09-0 [13C5]-1,2-di-O-acetyl-3,5-di-O-benzoyl-α,β-D-ribofuranose 
• 159496-08-9 C₄⁽¹³⁾C₅H₁₆O₇S 
• 503173-76-0 [ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)-5-methyluracil 
• 666824-07-3 C₁₇⁽¹³⁾C₅H₄₀N₂O₇Si₂ 
• 666824-08-4 C₁₇⁽¹³⁾C₅H₄₀N₂O₆Si₂ 
• 159496-17-0 D-[ribose-13C₅]-5-methyluridine 

Relevant articles and documents

NMR Spectroscopic Determination of the Solution Structure of a Branched Nucleic Acid from Residual Dipolar Couplings by Using Isotopically Labeled Nucleotides

Only a small set of magnetic-field-induced residual dipolar couplings is required to determine the global structure of branched nucleic acids. This is demonstrated for the example of the Holliday junction (shown schematically) after 13C labelin

Synthesis of (5'S)-1;1',2',3',4',5'-13C5>-Thymidine via Stereoselective Deuteration of a 5-Oxoribose Derivative

(5'S)-1:1',2'3'4'5'-13C5>-Thymidine has been synthesized by a stereoselective deuteride transfer reaction from (-)- or (+)-1>-isobornyloxymagnesium bromide to a 5-oxoribose derivative, which can be readily prepared from 6>-D-glucose.The overall yield from D-glucose to thymidine was 27percent.The various nucleosides with a stereoselective 2H-label together with 13C at the C5' position, which have become available by the present method, will be quite useful for stereospecific assignment of the diastereotopic C5' methylene signals, and also for conformational analyses of the O5'-C5' bonds in nucleic acid oligomers.