948092-63-5

Upstream product

• 948092-62-4 C₃₁H₄₃N₃O₉S 
• 185563-98-8 3S-3-amino-2-(2,4,6-trimethylbenzenesulfonylamino)propionic acid tert-butyl ester 
• 185563-96-6 N₂-(2,4,6-trimethylbenzenesulfonyl)-L-asparagine 
• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 
• 865436-07-3 2S,4R-4-tert-butoxycarbonylmethoxy-2-hydroxymethylpyrrolidine-1-carboxylic acid benzyl ester 
• 865436-06-2 2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 948092-61-3 2S,4R-2-(tert-butyldimethylsilanyloxymethyl)-4-carboxymethoxypyrrolidine-1-carboxylic acid benzyl ester 
• 773-64-8 2-mesitylenesulphonyl chloride 

Relevant academic research and scientific papers

Design and synthesis of a new class of selective integrin α5β1 antagonists

Starting from the structure of integrin αvβ3 in a complex with a peptidic ligand plus SAR data on nonpeptidic ligands, we derived a new class of integrin α5β1 antagonists (1). Several synthesis strategies were applied to evaluate the chemical space around