1856-65-1

Upstream product

• 79-77-6 (E)-β-ionone 
• 105-34-0 methyl 2-cyanoacetate 
• 372-09-8 cyanoacetic acid 

Downstream Products

• 92728-58-0 (4E)-3-methylene-5-(2,6,6-trimethylcyclohex-1-en-1-yl)pent-4-enenitrile 
• 92728-58-0 (Z)-3-Methylene-5-(2,6,6-trimethyl-cyclohex-1-enyl)-pent-4-enenitrile 
• 5299-99-0 (2Z,4E)-3-methyl-5-(2’,6’,6’-trimethylcyclohex-1’-en-1’-yl)-penta-2,4-dienenitrile 
• 5299-98-9 (2E,4E)-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienenitrile 
• 14398-42-6 (2E,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienoic acid 
• 3917-39-3 (2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexenyl)-2,4-pentadien-1-ol 
• 3917-41-7 (2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal 
• 862098-80-4 6-Methyl-8-<1.3.3-trimethyl-cyclohexen-(1)-yl-(2)>-octatrien-(3.5.7)-on-(2) 
• 105175-91-5 3-methyl-5-(2’,6’,6’-trimethylcyclohex-1’-en-1’-yl)-penta-2,4-dienenitrile 

Relevant academic research and scientific papers

Base-induced decarboxylation of polyunsaturated α-cyano acids derived from malonic acid: Synthesis of sesquiterpene nitriles and aldehydes with β-, φ-, and ψ-end groups

Catalytic base-induced decarboxylation of polyunsaturated α-cyano-β-methyl acids derived from malonic acid led to the corresponding nitriles 3 (Schemes 2 and 3), 6 (Scheme 5), and 9 (Scheme 6). This decarboxylation occurred with previous deconjugation of

New preparation of an important synthon for vitamin A synthesis

The "C-18 ketone" 1, key intermediate for vitamin A synthesis, is prepared in a few steps from β-ionone 3 via β-ionylidene acetonitrile 2 (32% overall yield).