185672-53-1

Upstream product

• 288-88-0 1,2,4-Triazole 
• 40615-37-0 3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3,4-dihydrothymidine 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Downstream Products

• 185672-54-2 Acetic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{5-methyl-2-oxo-4-[(pyren-1-ylmethyl)-amino]-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 
• 812700-25-7 Acetic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[6-(9,10-dioxo-9,10-dihydro-anthracen-1-ylamino)-hexylamino]-5-methyl-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 
• 185672-55-3 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-4-[(pyren-1-ylmethyl)-amino]-1H-pyrimidin-2-one 
• 812700-26-8 1-[6-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-ylamino)-hexylamino]-anthraquinone 

Relevant academic research and scientific papers

Synthesis of modified oligonucleotides containing 4-guanidino-2-pyrimidinone nucleobases

Oligonucleotides incorporating 4-guanidino-2-pyrimidinone nucleobases have been prepared. These nucleobase analogues were designed to mimic the double hydrogen bond donor pattern of protonated cytosines in parallel triple helices. Guanidine-, N-methyl-, N

Insertion of 5-methyl-N4-(1-pyrenylmethyl)cytidine into DNA. Duplex, three-way junction and tripler stabilities

5'-O-(4,4'-Dimethoxytrityl)-5-methyl-N4-(1-pyrenylmethyl)cytidine (5) was prepared by reaction of 1-pyrenylmethylamine with an appropriate protected-4-(1,2,4-triazolyl)thymidine derivative which was synthesized from 5-O-DMT protected thymidine by acetylation with acetic anhydride and subsequent reaction with triethylamine, 1,2,4-triazole and POCl3. Stabilities are reported for DNA duplexes, three-way junctions and triplexes when 5 is inserted. Most interestingly, the three-way junctions are stabilized when 5 is used for insertion into the junction region. This break-through for recognizing the foot of a stem could have far-reaching importance because new targets for antisense oligos is now rendered possible on intact secondary structures.