3'-O-acetyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

Base Information

Chemical Name:3'-O-acetyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside
CAS No.:185672-53-1
Molecular Formula:C₃₅H₃₅N₅O₇
Molecular Weight:637.692
Hs Code.:

Synonyms:3'-O-acetyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

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Chemical Property of 3'-O-acetyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

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Technology Process of 3'-O-acetyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

There total 2 articles about 3'-O-acetyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 288-88-0
1,2,4-Triazole

: 40615-37-0
3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3,4-dihydrothymidine

: 185672-53-1
3'-O-acetyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

Guidance literature:: With triethylamine; trichlorophosphate; In acetonitrile; for 3h; Ambient temperature;
DOI:10.1016/S0040-4020(96)00933-7

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 185672-53-1
3'-O-acetyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / pyridine / 1.) 0 deg C, 4 h, 2.) RT, 22 h

2: 91 percent / Et₃N, POCl₃ / acetonitrile / 3 h / Ambient temperature

With pyridine; triethylamine; trichlorophosphate; In acetonitrile;
DOI:10.1016/S0040-4020(96)00933-7