185686-39-9

Upstream product

• 66408-80-8 (2E,6E)-2,6-dimethyl-8-((tetrahydro-2H-pyran-2-yl)oxy)octa-2,6-dien-1-ol 
• 81449-01-6 4-(hydroxymethyl)benzophenone 
• 32752-54-8 4-(bromomethyl)benzophenone 
• 59632-99-4 geranyl 2-tetrahydropyranyl ether 
• 106-24-1 Geraniol 
• 110-87-2 3,4-dihydro-2H-pyran 

Downstream Products

• 185686-43-5 [4-((2E,6E)-8-Bromo-2,6-dimethyl-octa-2,6-dienyloxymethyl)-phenyl]-phenyl-methanone 
• 766504-20-5 (E,E,E)-[4-(9'-pyrophosphono-2',6'-dimethyl-2',6',8'-nonatrienyloxymethyl)-phenyl]-phenyl-methanone 
• 496042-84-3 (E,E,E)-[4-(9'-diethylphosphono-2',6'-dimethyl-2',6',8'-nonatrienyloxymethyl)-phenyl]-phenyl-methanone 
• 496042-86-5 (E,E,E)-[4-(9'-phosphono-2',6'-dimethyl-2',6',8'-nonatrienyloxymethyl)-phenyl]-phenyl-methanone 
• 496042-81-0 (E,E)-3,7-dimethyl-8-(4'-benzoylbenzyloxy)-2,6-octadienal 
• 185686-41-3 (E,E)-[4-(8-hydroxy-2',6'-dimethyl-octa-2',6'-dienyloxymethyl)-phenyl]-methanone 

Relevant academic research and scientific papers

Synthesis of vinyl pyrophosphonate analogues of farnesyl pyrophosphate: New potential inhibitors of farnesyl protein transferase

The synthesis of new bioisosteric analogues of farnesyl pyrophosphate where a vinyl pyrophosphonate replaced the pyrophosphate moiety is described. These compounds have been prepared using a Horner-Wadsworth-Emmons procedure and a modified Michelson react

Farnesyl and geranylgeranyl pyrophosphate analogs incorporating benzoylbenzyl ethers: Synthesis and inhibition of yeast protein farnesyltransferase

The syntheses of two photoactive analogs (1a and 1b) of farnesyl pyrophosphate that incorporate stable ether-linked benzophenones are described. Compounds 1a and 1b were prepared from geraniol in 17% overall yield. Both in and 1b are competitive inhibitors of yeast protein farnesyltransferase with respect to farnesyl pyrophosphate and have K1 values of 45 nM and 49 nM. Upon photolysis for twelve hours, 1a and 1b both inactivate the enzyme by 40%. Copyright (C) 1996 Elsevier Science Ltd.